Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) outbreak has become a global public health
emergency and has led to devastating results. Mounting evidence proposes that the disease …

Tackling the cytokine storm in COVID-19, challenges and hopes

SM Abdin, SM Elgendy, SK Alyammahi, DW Alhamad… - Life Sciences, 2020 - Elsevier
The outbreak of Coronavirus disease 2019 (COVID-19) is the current world health concern,
presenting a public health dilemma with ascending morbidity and mortality rates exceeding …

Role of monocytes/macrophages in Covid-19 pathogenesis: implications for therapy

J Gómez-Rial, I Rivero-Calle, A Salas… - Infection and Drug …, 2020 - Taylor & Francis
cov-Abstract Emerging studies from SARS-CoV-2-infected patients indicate a preponderant
role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to …

Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex

AC Petrey, F Qeadan, EA Middleton… - Journal of Leucocyte …, 2021 - academic.oup.com
COVID-19 rapidly emerged as a crippling public health crisis in the last few months, which
has presented a series health risk. Understanding of the immune response and biomarker …

[HTML][HTML] Cytokine storm intervention in the early stages of COVID-19 pneumonia

X Sun, T Wang, D Cai, Z Hu, H Liao, L Zhi, H Wei… - Cytokine & growth factor …, 2020 - Elsevier
Clinical intervention in patients with corona virus disease 2019 (COVID-19) has
demonstrated a strong upregulation of cytokine production in patients who are critically ill …

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …

Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
caused the greatest pandemic of our century. Many of the deaths related to it are due to a …