Potential mechanisms for COVID-19 induced anosmia and dysgeusia

AA Eshraghi, M Mirsaeidi, C Davies, FF Telischi… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is an emerging pandemic infecting more than 11 million people and leading to
more than 544,722 deaths worldwide at the time of writing this report. Despite the …

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

J Meinhardt, J Radke, C Dittmayer, J Franz… - Nature …, 2021 - nature.com
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events …

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

M Khan, SJ Yoo, M Clijsters, W Backaert, A Vanstapel… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure …

Comparative pathology of the nasal epithelium in K18-hACE2 Tg mice, hACE2 Tg mice, and hamsters infected with SARS-CoV-2

P Yu, W Deng, L Bao, Y Qu, Y Xu, W Zhao… - Veterinary …, 2022 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes severe viral
pneumonia and is associated with a high fatality rate. A substantial proportion of patients …

Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium

JB Finlay, DH Brann, R Abi Hachem, DW Jang… - Science translational …, 2022 - science.org
SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss.
Although these alterations are often transient, many patients with COVID-19 exhibit olfactory …

The cellular basis of loss of smell in 2019-nCoV-infected individuals

K Gupta, SK Mohanty, A Mittal, S Kalra… - Briefings in …, 2021 - academic.oup.com
A prominent clinical symptom of 2019-novel coronavirus (nCoV) infection is
hyposmia/anosmia (decrease or loss of sense of smell), along with general symptoms such …

Mid-term MRI evaluation reveals microstructural white matter alterations in COVID-19 fully recovered subjects with anosmia presentation

L Pelizzari, M Cazzoli, S Lipari… - Therapeutic …, 2022 - journals.sagepub.com
Background: Little is still known about the mid/long-term effects of coronavirus disease 2019
(COVID-19) on the brain, especially in subjects who have never been hospitalized due to …

The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international …

GC Román, PS Spencer, J Reis, A Buguet… - Journal of the …, 2020 - Elsevier
A comprehensive review of the neurological disorders reported during the current COVID-19
pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system …

Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review

AS Zubair, LS McAlpine, T Gardin, S Farhadian… - JAMA …, 2020 - jamanetwork.com
Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in
December 2019, causing human coronavirus disease 2019 (COVID-19), which has now …

[HTML][HTML] Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

M Chen, A Pekosz, JS Villano, W Shen… - The Journal of …, 2024 - Am Soc Clin Investig
SARS-CoV-2 infection of the upper airway and the subsequent immune response are early,
critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro …