Purpose: Retinal vasomotor activity can be regulated by two major endothelial enzymes,
nitric oxide synthase (NOS) and cyclooxygenase (COX). The vascular arginase also …

Aims/hypothesis A reduction in retinal blood flow occurs early in diabetes and is likely to be
involved in the development of diabetic retinopathy. We hypothesise that activation of the …

We have shown previously that diabetes causes increases in retinal arginase activity that
are associated with impairment of endothelial cell (EC)-dependent vasodilation and …

Purpose: Hyperglycemia, a hallmark of diabetes mellitus, is associated with retinal
inflammation and impairment of endothelium-dependent nitric oxide (NO)–mediated dilation …

Purpose.: Although hyperglycemia is implicated in retinal vascular dysfunction associated
with the development of diabetic retinopathy, the temporal influence of hyperglycemia on …

Retinal neovascularization is a leading cause of visual disability. Retinal diseases involving
neovascularization all follow the same progression, beginning with vascular inflammatory …

Endothelial dysfunction has been implicated in the pathogenesis of diabetic vascular
disorders such as diabetic retinopathy. We hypothesized that either local endogenous nitric …

Purpose.: Although the arteriolar segment contributes to flow regulation, there is sparse
information at the single microvessel level on how vasomotor function is regulated in the …

Purpose: To determine whether insulin induces nitric oxide (NO) formation in retinal
microvessels and to examine the effects of high glucose on the formation of NO. Methods …

Purpose.: Because retinal vascular disease is associated with ischemia and increased
oxidative stress, the vasodilator function of retinal arterioles was examined after retinal …