Immunological backbone of uveal melanoma: is there a rationale for immunotherapy?

E Rossi, G Schinzari, IG Zizzari, BA Maiorano… - Cancers, 2019 - mdpi.com
No standard treatment has been established for metastatic uveal melanoma (mUM).
Immunotherapy is commonly used for this disease even though UM has not been included …

Clinical trials in metastatic uveal melanoma: Immunotherapy

M Orloff - Ocular Oncology and Pathology, 2021 - karger.com
Background: Uveal melanoma (UM) is a rare subtype of melanoma that generally has a poor
prognosis once it has metastasized. Clinical trials evaluating immune checkpoint inhibitors …

Immunotherapies for the treatment of uveal melanoma—history and future

TE Schank, JC Hassel - Cancers, 2019 - mdpi.com
Background: Uveal melanoma is the most common primary intraocular malignancy among
adults. It is, nevertheless, a rare disease, with an incidence of approximately one case per …

Immunotherapy in uveal melanoma: novel strategies and opportunities for personalized treatment

C Masaoutis, S Kokkali… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Uveal melanoma (UM) is the most common intraocular cancer and represents a
discrete subtype of melanoma. Metastatic disease, which occurs in half of patients, has a …

Immunotherapy for uveal melanoma-current knowledge and perspectives

S Kaštelan, AG Antunica, LB Oresković… - Current medicinal …, 2020 - ingentaconnect.com
Uveal melanoma is the most prevalent primary intraocular tumour in adults with the
incidence between five and six cases per million people in the United States and Europe …

[HTML][HTML] Uveal melanoma: identifying immunological and chemotherapeutic targets to treat metastases

MJ Jager, M Dogrusöz, SE Woodman - Asia-Pacific Journal of …, 2017 - Elsevier
Uveal melanoma is an intraocular malignancy that, depending on its size and genetic make-
up, may lead to metastases in up to 50% of cases. Currently, no therapy has been proven to …

[HTML][HTML] Ipilimumab plus nivolumab for patients with metastatic uveal melanoma: a multicenter, retrospective study

YG Najjar, K Navrazhina, F Ding, R Bhatia… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Uveal melanoma (UM) is the most common intraocular malignancy in adults. In
contrast to cutaneous melanoma (CM), there is no standard therapy, and the efficacy and …

Role of immune checkpoint inhibitors and novel immunotherapies in uveal melanoma

V Jindal - Chinese Clinical Oncology, 2018 - cco.amegroups.org
Uveal melanoma (UM) is one of the rare malignancies, which can be lethal despite local
treatment. Treatment options available now can control UM in early stages, but once it …

Nivolumab and Ipilimumab in the Treatment of Metastatic Uveal Melanoma: A Single‐Center Experience

V Karivedu, I Eldessouki, A Taftaf, Z Zhu… - Case reports in …, 2019 - Wiley Online Library
Background. Metastatic uveal melanoma (MUM) is associated with a poor prognosis, with a
median overall survival (OS) of 4–15 months. Despite new insights into the genetic and …

Pembrolizumab as first-line treatment for metastatic uveal melanoma

E Rossi, MM Pagliara, D Orteschi, T Dosa… - Cancer Immunology …, 2019 - Springer
Background No standard treatment has been defined for metastatic uveal melanoma (mUM).
Although clinical trials testing Nivolumab/Pembrolizumab for cutaneous melanoma did not …