Astrocytes in schizophrenia
T Notter - Brain and Neuroscience Advances, 2021 - journals.sagepub.com
Schizophrenia is a severe and clinically heterogenous mental disorder affecting
approximately 1% of the population worldwide. Despite tremendous achievements in the …
approximately 1% of the population worldwide. Despite tremendous achievements in the …
Synaptic changes in the brain of subjects with schizophrenia
G Faludi, K Mirnics - International Journal of Developmental Neuroscience, 2011 - Elsevier
Clinical, epidemiological, neuroimaging and postmortem data all suggest schizophrenia is a
neurodevelopmental disorder, and that synaptic disturbances might play a critical role in …
neurodevelopmental disorder, and that synaptic disturbances might play a critical role in …
[PDF][PDF] Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
The circuitry of dopamine system regulation and its disruption in schizophrenia: insights into treatment and prevention
Despite evidence for a role of the dopamine system in the pathophysiology of schizophrenia,
there has not been substantial evidence that this disorder originates from a pathological …
there has not been substantial evidence that this disorder originates from a pathological …
[HTML][HTML] The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …
between genetic and environmental risk factors. The immune system is now known to play …
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Multiple lines of evidence in schizophrenia, from brain imaging, studies in postmortem
brains, and genetic association studies, have implicated oligodendrocyte and myelin …
brains, and genetic association studies, have implicated oligodendrocyte and myelin …
Evidence for progression of brain structural abnormalities in schizophrenia: beyond the neurodevelopmental model
Objective Clinical, neuroimaging, neuropathological and neuropsychological evidence
suggests that, in schizophrenia, there is structural and functional disturbance of the …
suggests that, in schizophrenia, there is structural and functional disturbance of the …
Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia
F Corsi-Zuelli, B Deakin - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
It is widely held that schizophrenia involves an active process of peripheral inflammation that
induces or reflects brain inflammation with activation of microglia, the brain's resident …
induces or reflects brain inflammation with activation of microglia, the brain's resident …
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
Schizophrenia,“just the facts”: What we know in 2008: Part 3: Neurobiology
MS Keshavan, R Tandon, NN Boutros… - Schizophrenia …, 2008 - Elsevier
Investigating the neurobiological basis of schizophrenia is a critical step toward establishing
validity of psychiatric diagnoses, predicting outcome, delineating causative mechanisms and …
validity of psychiatric diagnoses, predicting outcome, delineating causative mechanisms and …