Overcoming barriers: the endothelium as a linchpin of coronavirus disease 2019 pathogenesis?

D Gustafson, S Raju, R Wu, C Ching… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Coronavirus disease 2019 (COVID-19) is a global pandemic involving> 5 500
000 cases worldwide as of May 26, 2020. The culprit is the severe acute respiratory …

Understanding the link between obesity and severe COVID-19 outcomes: causal mediation by systemic inflammatory response

AS Foulkes, C Selvaggi, D Shinnick… - The Journal of …, 2022 - academic.oup.com
Background Obesity is an established risk factor for severe COVID-19 outcomes. The
mechanistic underpinnings of this association are not well-understood. Objective To …

Endothelial dysfunction in COVID-19: potential mechanisms and possible therapeutic options

MC Pelle, I Zaffina, S Lucà, V Forte, V Trapanese… - Life, 2022 - mdpi.com
SARS-CoV-2, a novel coronavirus found in Wuhan (China) at the end of 2019, is the
etiological agent of the current pandemic that is a heterogeneous disease, named …

Endothelial dysfunction in COVID-19: A potential predictor of long-COVID?

A Seitz, P Ong - International Journal of …, 2022 - internationaljournalofcardiology.com
The coronavirus disease of 2019 (COVID-19) pandemic has dominated everyday life around
the globe for almost two years now. While effective COVID-19 vaccines became available …

Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis

SMM Aghili, M Ebrahimpur, B Arjmand… - International journal of …, 2021 - nature.com
Background Recent studies have shown that obesity is associated with the severity of
coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity …

Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19)

AH Norooznezhad, K Mansouri - Microvascular research, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has been led to a pandemic emergency. So far …

COVID-19 and the vasculature: current aspects and long-term consequences

B Martínez-Salazar, M Holwerda, C Stüdle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …

Obesity, inflammation, and mortality in COVID-19: an observational study from the public health care system of New York City

L Palaiodimos, R Ali, HO Teo, S Parthasarathy… - Journal of Clinical …, 2022 - mdpi.com
Severe obesity increases the risk for negative outcomes in patients with coronavirus disease
2019 (COVID-19). Our objectives were to investigate the effect of BMI on in-hospital …

Endothelial dysfunction in SARS-CoV-2 infection

F Nappi, SS Avtaar Singh - Biomedicines, 2022 - mdpi.com
One of the hallmarks of the SARS-CoV-2 infection has been the inflammatory process that
played a role in its pathogenesis, resulting in mortality within susceptible individuals. This …

Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients

V Montiel, I Lobysheva, L Gerard, M Vermeersch… - …, 2022 - thelancet.com
Background SARS-CoV-2 targets endothelial cells through the angiotensin-converting
enzyme 2 receptor. The resulting endothelial injury induces widespread thrombosis and …