SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

The role of obesity in inflammatory markers in COVID-19 patients

JN McNeill, ES Lau, SM Paniagua, EE Liu… - Obesity research & …, 2021 - Elsevier
Obesity has emerged as a significant risk factor for severe COVID-19 worldwide. Given both
COVID-19 infection and obesity have been associated with increased systemic …

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

EJ Kooistra, AH de Nooijer, WJ Claassen… - International Journal of …, 2021 - nature.com
Background/objectives Obesity appears to be an independent risk factor for ICU admission
and a severe disease course in COVID-19 patients. An aberrant inflammatory response and …

Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review

G Mavraganis, MA Dimopoulou… - European Journal of …, 2022 - Wiley Online Library
Background Accumulating evidence suggests that endothelial dysfunction is implicated in
the pathogenesis and severity of coronavirus disease 2019 (COVID‐19). In this context …

Systemic inflammation and COVID-19 mortality in patients with major noncommunicable diseases: chronic coronary syndromes, diabetes and obesity

AL Buicu, S Cernea, I Benedek, CF Buicu… - Journal of Clinical …, 2021 - mdpi.com
COVID-19 is currently considered an inflammatory disease affecting the entire organism. In
severe forms, an augmented inflammatory response leads to the fulminant “cytokine storm” …

Arterial thrombosis and coronavirus disease 2019

RD McBane - Mayo Clinic Proceedings, 2021 - mayoclinicproceedings.org
Thrombotic complications from severe acute respiratory syndrome coronavirus-2(SARS-CoV-
2) infections (coronavirus disease 2019 [COVID-19]) have generated considerable interest …

Endothelial dysfunction in acute and long standing COVID− 19: A prospective cohort study

E Oikonomou, N Souvaliotis, S Lampsas, G Siasos… - Vascular …, 2022 - Elsevier
Abstract Background Coronavirus disease-19 (COVID-19) is implicated by active
endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in …

COVID-19 and microvascular disease: pathophysiology of SARS-CoV-2 infection with focus on the renin-angiotensin system

DA Kasal, A De Lorenzo, E Tibirica - Heart, Lung and Circulation, 2020 - Elsevier
The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
infected millions of people, with thousands of fatalities. It has prompted global efforts in …

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

S Pons, S Fodil, E Azoulay, L Zafrani - Critical care, 2020 - Springer
In severe SARS-CoV-2 infections, emerging data including recent histopathological studies
have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction …

Factors associated with increased morbidity and mortality of obese and overweight COVID-19 patients

A Magdy Beshbishy, HF Hetta, DE Hussein, AA Saati… - Biology, 2020 - mdpi.com
Overweight and obesity are defined as an unnecessary accumulation of fat, which poses a
risk to health. It is a well-identified risk factor for increased mortality due to heightened rates …