Ageing is an inevitable biological process characterized by progressive decline in
physiological functions. It is a complex natural phenomenon that will cause structural and …

Background: Aging is characterized by the gradual loss of physiological integrity, resulting in
impaired function and easier death. This deterioration is a major risk factor for major human …

Background Aging human skin undergoes significant morphological and functional changes
such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier …

Aging is a critical risk factor for developing many diseases such as skin diseases. Aging skin
is caused by the decline of regenerative potential and function of tissues. Here, we aim to …

Tissue transcriptomics is used to uncover molecular dysregulations underlying diseases.
However, the majority of transcriptomics studies focus on single diseases with limited …

The proteome comprises all proteins of a cell or organism. To carry their catalytic and
structure-related functions, proteins must be correctly folded into their unique native three …

Skin aging is a complex process involving intricate genetic and environmental factors. In this
study, we performed a comprehensive analysis of the transcriptional regulatory landscape of …

Human skin is the most widespread and abundant type of tissue in the human body. With the
passage of time, most of our organs, including a substantial part of the skin, tend to undergo …

The skin provides protection against environmental stress. However, intrinsic and extrinsic
aging causes significant alteration to skin structure and components, which subsequently …

Objective As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased
action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting …