[HTML][HTML] Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

C Phetsouphanh, DR Darley, DB Wilson, A Howe… - Nature …, 2022 - nature.com
A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection
develop post-acute COVID syndrome (long COVID (LC)) lasting longer than 12 weeks. Here …

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …

[HTML][HTML] A multi-omics based anti-inflammatory immune signature characterizes long COVID-19 syndrome

JJ Kovarik, A Bileck, G Hagn, SM Meier-Menches… - Iscience, 2023 - cell.com
To investigate long COVID-19 syndrome (LCS) pathophysiology, we performed an
exploratory study with blood plasma derived from three groups: 1) healthy vaccinated …

Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery

C Feng, J Shi, Q Fan, Y Wang, H Huang, F Chen… - Nature …, 2021 - nature.com
SARS-CoV-2 vaccination has been launched worldwide to build effective population-level
immunity to curb the spread of this virus. The effectiveness and duration of protective …

Silent battles: immune responses in asymptomatic SARS-CoV-2 infection

N Le Bert, T Samandari - Cellular & Molecular Immunology, 2024 - nature.com
SARS-CoV-2 infections manifest with a broad spectrum of presentations, ranging from
asymptomatic infections to severe pneumonia and fatal outcomes. This review centers on …

Single-cell landscape of immunological responses in patients with COVID-19

JY Zhang, XM Wang, X Xing, Z Xu, C Zhang… - Nature …, 2020 - nature.com
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Heightened circulating interferon-inducible chemokines, and activated pro-cytolytic Th1-cell phenotype features covid-19 aggravation in the second week of illness

C Tincati, ES Cannizzo, M Giacomelli… - Frontiers in …, 2020 - frontiersin.org
Covid-19 features a delayed onset of critical illness occurring approximately one week from
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

DM Altmann, CJ Reynolds, G Joy, AD Otter… - Nature …, 2023 - nature.com
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in
Long Covid is whether there is a contributory role of abnormal immunity during acute …