Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation
HA Anderson, EM Hiltbold, PA Roche - Nature immunology, 2000 - nature.com
The plasma membranes of eukaryotic cells are not uniform and possess distinct cholesterol–
and sphingolipid–rich raft microdomains that are enriched in proteins known to be essential …
and sphingolipid–rich raft microdomains that are enriched in proteins known to be essential …
Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells
DR Drake, TJ Braciale - The Journal of Immunology, 2001 - journals.aai.org
Physically distinct cholesterol/sphingolipid-rich plasma membrane microdomains, so-called
lipid rafts, have been recognized to play an important regulatory role in various cellular …
lipid rafts, have been recognized to play an important regulatory role in various cellular …
Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells
Here we show that activated Th1 and Th2 cells have distinct patterns of membrane
compartmentalization into lipid rafts. TCR complex members are recruited efficiently to rafts …
compartmentalization into lipid rafts. TCR complex members are recruited efficiently to rafts …
The roles of membrane microdomains (rafts) in T cell activation
V Hor̆ejs̆í - Immunological reviews, 2003 - Wiley Online Library
Detergent‐resistant membrane microdomains enriched in sphingolipids, cholesterol and
glycosylphosphatidylinositol‐anchored proteins play essential roles in T cell receptor (TCR) …
glycosylphosphatidylinositol‐anchored proteins play essential roles in T cell receptor (TCR) …
Lipid rafts and B cell signaling
N Gupta, AL DeFranco - Seminars in cell & developmental biology, 2007 - Elsevier
B cells comprise an essential component of the humoral immune system. They are equipped
with the unique ability to synthesize and secrete pathogen-neutralizing antibodies, and …
with the unique ability to synthesize and secrete pathogen-neutralizing antibodies, and …
Membrane compartmentation is required for efficient T cell activation
R Xavier, T Brennan, Q Li, C McCormack, B Seed - Immunity, 1998 - cell.com
The plasma membrane of mammalian cells contains detergent-resistant membrane rafts
enriched in glycosphingolipids and cholesterol. Although several important signaling …
enriched in glycosphingolipids and cholesterol. Although several important signaling …
Accumulation of raft lipids in T‐cell plasma membrane domains engaged in TCR signalling
Activating stimuli for T lymphocytes are transmitted through plasma membrane domains that
form at T‐cell antigen receptor (TCR) signalling foci. Here, we determined the molecular …
form at T‐cell antigen receptor (TCR) signalling foci. Here, we determined the molecular …
The role of lipid rafts in T cell antigen receptor (TCR) signalling
Copyright 2000 Academic PressPlasma membranes of many cell types contain domains
enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell …
enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell …
T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis
JH Cho, HO Kim, CD Surh, J Sprent - Immunity, 2010 - cell.com
T cell receptor (TCR) contact with self ligands keeps T cells alive and is shown here to cause
naive CD8+, but not CD4+, T cells to be hypersensitive to certain γ c cytokines, notably …
naive CD8+, but not CD4+, T cells to be hypersensitive to certain γ c cytokines, notably …
Analysis of lipid rafts in T cells
S Thomas, A Preda-Pais, S Casares… - Molecular immunology, 2004 - Elsevier
The plasma membrane of T cells is made of a combination of glycosphingolipids and protein
receptors organized in glycolipoprotein microdomains termed lipid rafts. The structural …
receptors organized in glycolipoprotein microdomains termed lipid rafts. The structural …