Although it is not easy to investigate the regulatory basis of developmental processes in
most mammalian tissues, the mouse kidney has several distinct advantages as a model …

For more than 40 years now, the developing kidney has served as a model paradigm for
epithelial‐mesenchymal interactions. The principles of inductive signaling, epithelial cell …

Kidney development starts with an epithelial bud and a domain of committed mesenchyme
inducing one another so that the former gives a bifurcating duct system and the latter …

In recent years, gene inactivation in the mouse and other model systems has shed new light
on the processes of inductive tissue interactions and morphogenesis. These studies have …

Many of the signaling pathways that regulate tissue specification and coordinate cellular
differentiation during embryogenesis have been identified over the last decade. These …

The mammalian kidney consists of highly specialised cells that function in an integrated
manner to maintain homeostasis of body fluids, electrolytes and nutrients. Formation of …

Embryonic kidney is ideal for the study of epithelial morphogenesis—rich in developmental
processes, accessible and clinically important. Interactions between mesenchyme and the …

The kidney derives from a set of inductive interactions between two tissues, a blastema of
metanephric mesenchyme (MM) that arises from within the intermediate mesoderm, and the …

The development of the mature mammalian kidney begins with the invasion of metanephric
mesenchyme by ureteric bud. Mesenchymal cells near the bud become induced and convert …

As in most organs, the emerging theme in kidney development is the importance of cross-
talk between several tissues and cell lineages to allow morphogenesis to proceed in a …