Two distinct immunopathological profiles in autopsy lungs of COVID-19

R Nienhold, Y Ciani, VH Koelzer, A Tzankov… - Nature …, 2020 - nature.com
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide …

COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases

S Valdebenito, S Bessis, D Annane… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …

Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases

Q Liu, Y Shi, J Cai, Y Duan, R Wang… - National science …, 2020 - academic.oup.com
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents
should provide insights into the disease characteristics and facilitate the development of …

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

B Vijayakumar, K Boustani, PP Ogger, A Papadaki… - Immunity, 2022 - cell.com
Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for
many months. We delineated the immune-proteomic landscape in the airways and …

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

M Wu, Y Chen, H Xia, C Wang… - Proceedings of the …, 2020 - National Acad Sciences
Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, has
resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis …

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

W Zhang, BY Chua, KJ Selva, L Kedzierski… - Nature …, 2022 - nature.com
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …

Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

A Saris, TDY Reijnders, EJ Nossent, AR Schuurman… - Thorax, 2021 - thorax.bmj.com
Background Knowledge of the pathophysiology of COVID-19 is almost exclusively derived
from studies that examined the immune response in blood. We here aimed to analyse the …

COVID‐19 immunopathology: from acute diseases to chronic sequelae

M Arish, W Qian, H Narasimhan… - Journal of medical …, 2023 - Wiley Online Library
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …

Immune signatures underlying post-acute COVID-19 lung sequelae

IS Cheon, C Li, YM Son, NP Goplen, Y Wu… - Science …, 2021 - science.org
Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …

Tissue proteomic analysis identifies mechanisms and stages of immunopathology in fatal COVID-19

CD Russell, A Valanciute, NN Gachanja… - American journal of …, 2022 - atsjournals.org
Immunopathology occurs in the lung and spleen in fatal coronavirus disease (COVID-19),
involving monocytes/macrophages and plasma cells. Antiinflammatory therapy reduces …