PROBLEM: To investigate the proposal that NK cells in decidua may control trophoblast
migration during implantation of the human placenta. METHOD: Use Mab specific for HLA‐G …

The establishment of the human placenta in early pregnancy is characterized by the
presence of large numbers of natural killer (NK) cells within the maternal decidua in close …

During the luteal phase and the early months of pregnancy, there is a dense mucosal
infiltration of CD56+ natural killer (NK) cells. These uterine NK cells have a phenotype …

Non‐classical MHC class I molecule HLA‐E is the ligand for CD94/NKG2 NK cell receptors.
Surface expression of HLA‐E requires binding of specific HLA class I leader sequences. The …

At the implantation site, the uterine mucosa (decidua) is infiltrated by large numbers of
natural killer (NK) cells. These NK cells are in close contact with the invading fetal …

During placentation the extravillous trophoblast (EVT) cells migrate through the decidua
towards the maternal spiral arteries. The walls of the arteries are then destroyed by …

Large numbers of natural killer cells are present within the maternal decidua close to the
extravillous trophoblast cells. Most of these natural killer cells express high levels of …

BACKGROUND: The interaction between decidual natural killer (NK) cells and alloantigens
expressed on fetal trophoblast cells are thought to be essential for successful implantation …

Immunogenetic studies suggest that interactions between maternal killer Ig-like receptor
(KIR) expressed by uterine NK (uNK) cells, and fetal HLA-C molecules on trophoblast …

The expression of natural killer (NK) cell receptors specific for HLA class I molecules has
been studied in CD56bright, CD3− NK cells isolated from the pregnant uterine mucosa, the …