Arrested development: suppression of NK cell function in the tumor microenvironment

L Riggan, S Shah, TE O'Sullivan - Clinical & Translational …, 2021 - Wiley Online Library
Natural killer (NK) cells are cytotoxic innate lymphocytes that protect against viral infection
and tumor metastasis. Despite their inherent ability to kill a broad range of virally infected …

Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment

AL Portillo, JK Monteiro, EA Rojas, TM Ritchie… - Frontiers in …, 2023 - frontiersin.org
The ability to expand and activate natural Killer (NK) cells ex vivo has dramatically changed
the landscape in the development of novel adoptive cell therapies for treating cancer over …

Tailoring Natural Killer cell immunotherapy to the tumour microenvironment

AD Barrow, M Colonna - Seminars in immunology, 2017 - Elsevier
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent
anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely …

NK cell plasticity in cancer

S Liu, P Dhar, JD Wu - Journal of Clinical Medicine, 2019 - mdpi.com
Natural killer (NK) cells are critical immune components in controlling tumor growth and
dissemination. Given their innate capacity to eliminate tumor cells without prior sensitization …

NK cells to cure cancer

C Di Vito, J Mikulak, E Zaghi, S Pesce… - Seminars in …, 2019 - Elsevier
Natural Killer (NK) cells are innate lymphocytes able to mediate immune-surveillance and
clearance of viral infected and tumor-transformed cells. Growing experimental and clinical …

The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies

T Bald, MF Krummel, MJ Smyth, KC Barry - Nature immunology, 2020 - nature.com
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …

Unleashing natural killer cells in the tumor microenvironment–the next generation of immunotherapy?

A Ben-Shmuel, G Biber, M Barda-Saad - Frontiers in immunology, 2020 - frontiersin.org
The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …

NK cells in the tumor microenvironment

C Guillerey - Tumor Microenvironment: Hematopoietic Cells–Part B, 2020 - Springer
Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …

NK cells are never alone: crosstalk and communication in tumour microenvironments

Y Zhou, L Cheng, L Liu, X Li - Molecular Cancer, 2023 - Springer
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

The adverse impact of tumor microenvironment on NK-cell

Z Hu, X Xu, H Wei - Frontiers in Immunology, 2021 - frontiersin.org
NK cells are considered an important component of innate immunity, which is the first line of
defensing against tumors and viral infections in the absence of prior sensitization. NK cells …