An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types …
signaling, and function. To better understand the functions and interactions of the cell types …
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Understanding the cell–cell interactions that control CNS development and function has
long been limited by the lack of methods to cleanly separate neural cell types. Here we …
long been limited by the lack of methods to cleanly separate neural cell types. Here we …
Molecular diversity and specializations among the cells of the adult mouse brain
A Saunders, EZ Macosko, A Wysoker, M Goldman… - Cell, 2018 - cell.com
The mammalian brain is composed of diverse, specialized cell populations. To
systematically ascertain and learn from these cellular specializations, we used Drop-seq to …
systematically ascertain and learn from these cellular specializations, we used Drop-seq to …
Brain transcriptome databases: a user's guide
Transcriptional programs instruct the generation and maintenance of diverse subtypes of
neural cells, establishment of distinct brain regions, formation and function of neural circuits …
neural cells, establishment of distinct brain regions, formation and function of neural circuits …
Molecular diversity of astrocytes with implications for neurological disorders
The astrocyte represents the most abundant yet least understood cell type of the CNS. Here,
we use a stringent experimental strategy to molecularly define the astrocyte lineage by …
we use a stringent experimental strategy to molecularly define the astrocyte lineage by …
Functional organization of the transcriptome in human brain
The enormous complexity of the human brain ultimately derives from a finite set of molecular
instructions encoded in the human genome. These instructions can be directly studied by …
instructions encoded in the human genome. These instructions can be directly studied by …
Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Nervous systems are composed of various cell types, but the extent of cell type diversity is
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …
Complexity and graded regulation of neuronal cell-type–specific alternative splicing revealed by single-cell RNA sequencing
The enormous cellular diversity in the mammalian brain, which is highly prototypical and
organized in a hierarchical manner, is dictated by cell-type–specific gene-regulatory …
organized in a hierarchical manner, is dictated by cell-type–specific gene-regulatory …
Single-cell sequencing of brain cell transcriptomes and epigenomes
Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …
transforming our understanding of the cellular building blocks of neural circuits. By directly …
mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex
The complexity of the adult brain is a result of both developmental processes and
experience-dependent circuit formation. One way to look at the differences between …
experience-dependent circuit formation. One way to look at the differences between …