Genetically predicted androgenic profiles and adverse cardiac markers: a sex‐specific Mendelian randomization study

JY Chen, M Ardissino, RK Reddy, AM Mason… - ESC Heart …, 2023 - Wiley Online Library
Aims Observational evidence suggests associations between sex hormone levels and heart
failure (HF). We used sex‐specific genetic variants associated with androgenic sex hormone …

EFFECT OF SEX HORMONE BINDING GLOBULIN AND TESTOSTERONE LEVELS ON HEART FAILURE AND CMR-DERIVED LEFT VENTRICULAR PARAMETERS …

JY Chen, M Ardissino, RK Reddy, A Mason… - Journal of the American …, 2023 - jacc.org
Background Heart failure is a major cause of morbidity among males and females. Previous
observational evidence has suggested an association between sex hormone levels and …

Pre‐diagnostic free androgen and estradiol levels influence heart failure risk in both women and men: A prospective cohort study in the UK Biobank

J Lim, M Hashemian, B Blechter… - European Journal of …, 2024 - Wiley Online Library
Aims Serum sex hormones have been linked to cardiovascular disease risk. However, their
roles in the pathogenesis of heart failure (HF) in both men and women are unclear. We …

Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study

JV Zhao, CM Schooling - Scientific Reports, 2021 - nature.com
Men are more vulnerable to ischemic heart disease (IHD) than women, possibly due to
testosterone. Correspondingly, sex hormone binding globulin (SHBG) which lowers …

[HTML][HTML] Causal effect of sex hormone-binding globulin and testosterone on coronary heart disease: a multivariable and network Mendelian randomization analysis

Y Li, S Si, L Hou, T Yuan, X Chen, C Liu, W Li… - International journal of …, 2021 - Elsevier
Background Although observational studies have shown an association between sex
hormone-binding globulin (SHBG), testosterone (T) and cardiovascular diseases (CVD) …

Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study

S Schaefer, MA Aydin, S Appelbaum… - ESC heart …, 2021 - Wiley Online Library
Aims The increased incidence of heart failure in men suggests that endogenous sex
hormones might play a role in the development of heart failure, but epidemiological data …

Complex association of sex hormones on left ventricular systolic function: insight into sexual dimorphism

JE Salem, LS Nguyen, N Hammoudi… - Journal of the American …, 2018 - Elsevier
Background Normal values of left ventricular ejection fraction (LVEF) and absolute values of
global longitudinal strain (GLS) are lower in men than in women. Data concerning the …

[PDF][PDF] Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure

Q Yang, Q Yang, X Wu, R Zheng, H Lin, S Wang… - Cell Reports …, 2024 - cell.com
The prevalence of heart failure (HF) subtypes, which are classified by left ventricular ejection
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …

The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey …

X Zhan, Y Liu, T Chen, H Wan, S Xiong, S Li… - Reproductive Biology …, 2024 - Springer
Background This study aimed to investigate the relationship between serum testosterone
levels and the risk of congestive heart failure (CHF) in adult males. Previous research has …

[HTML][HTML] Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: a Mendelian randomization investigation

CM Schooling, S Luo, SLA Yeung… - International journal of …, 2018 - Elsevier
Background Testosterone supplementation has been linked to increased cardiovascular
disease risk in some observational studies. The causal role of testosterone can be …