On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

SARS-CoV-2 Infection–Associated Hemophagocytic Lymphohistiocytosis: An Autopsy Series With Clinical and Laboratory Correlation

A Prilutskiy, M Kritselis, A Shevtsov… - American journal of …, 2020 - academic.oup.com
Objectives A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical
features of cytokine storm. However, clinicopathologic features diagnostic of …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

Humoral immune mechanisms involved in protective and pathological immunity during COVID-19

G Widjaja, AT Jalil, HS Rahman, WK Abdelbasset… - Human Immunology, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is
associated with excessive inflammation, as a main reason for severe condition and death …

The looming storm: blood and cytokines in COVID-19

S Kaur, R Bansal, S Kollimuttathuillam, AM Gowda… - Blood reviews, 2021 - Elsevier
A novel coronavirus termed as COVID-19 by WHO has been the causative agent of an
unprecedented pandemic in the history of humanity. The global burden of mortality and …

[HTML][HTML] Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position …

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical
illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure …

[HTML][HTML] Hemocytometric characteristics of COVID-19 patients with and without cytokine storm syndrome on the sysmex XN-10 hematology analyzer

RJH Martens, AJ van Adrichem… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives COVID-19 is an ongoing global pandemic. There is an urgent need for
identification and understanding of clinical and laboratory parameters related to progression …

Immunopathogenesis of coronavirus-induced acute respiratory distress syndrome (ARDS): potential infection-associated hemophagocytic lymphohistiocytosis

C Quan, C Li, H Ma, Y Li, H Zhang - Clinical Microbiology Reviews, 2020 - Am Soc Microbiol
The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China,
introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific …

[HTML][HTML] Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced …

[HTML][HTML] Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

R Hong, H Zhao, Y Wang, Y Chen, H Cai… - Bone marrow …, 2021 - nature.com
An excessive immune response during coronavirus disease (COVID-19) can induce
cytokine release syndrome (CRS), which is associated with life-threatening complications …