Use of tocilizumab for COVID-19-induced cytokine release syndrome: a cautionary case report

J Radbel, N Narayanan, PJ Bhatt - Chest, 2020 - Elsevier
Novel coronavirus disease 2019 (COVID-19) emerged in late December 2019 in Wuhan,
China. Since then, COVID-19 has become a pandemic affecting more than 4.1 million …

[HTML][HTML] Secondary HLH is uncommon in severe COVID‐19

H Wood, JR Jones, K Hui, T Mare, T Pirani… - British journal of …, 2020 - ncbi.nlm.nih.gov
Severe cases of COVID-19, caused by novel coronavirus SARS-CoV-2, have been
associated with a hyperinflammatory state. 1 This has been described as a form of …

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, CC Bortolasci, BK Puri, W Marx, A O'Neil… - Cytokine, 2021 - Elsevier
An analysis of published data appertaining to the cytokine storms of COVID-19, H1N1
influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) …

Neutrophil activation and neutrophil extracellular traps (NETs) in COVID‐19 ARDS and immunothrombosis

MC Cesta, M Zippoli, C Marsiglia… - European Journal of …, 2023 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is an acute inflammatory condition with a
dramatic increase in incidence since the beginning of the coronavirus disease 19 (COVID …

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) outbreak has become a global public health
emergency and has led to devastating results. Mounting evidence proposes that the disease …

The rheumatologist's role in COVID-19

RQ Cron, WW Chatham - The Journal of rheumatology, 2020 - jrheum.org
The novel coronavirus (severe acute respiratory syndrome; SARS-CoV-2) pandemic has
spread rapidly throughout the planet. It is believed to have originated in the Wuhan province …

[HTML][HTML] Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells

B Hafezi, L Chan, JP Knapp, N Karimi, K Alizadeh… - Cells, 2021 - mdpi.com
Cytokine storm syndrome is a cascade of escalated immune responses disposing the
immune system to exhaustion, which might ultimately result in organ failure and fatal …

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …

[HTML][HTML] Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis

AKG Melo, KM Milby, ALMA Caparroz, ACPN Pinto… - PloS one, 2021 - journals.plos.org
Objective To describe the laboratory parameters and biomarkers of the cytokine storm
syndrome associated with severe and fatal COVID-19 cases. Methods A search with …

[HTML][HTML] COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …