Selenium, selenoprotein P, and Alzheimer's disease: is there a link?

N Solovyev, E Drobyshev, G Bjørklund… - Free Radical Biology …, 2018 - Elsevier
The essential trace element, selenium (Se), is crucial to the brain but it may be potentially
neurotoxic, depending on dosage and speciation; Se has been discussed for decades in …

Selenium and selenocysteine: roles in cancer, health, and development

DL Hatfield, PA Tsuji, BA Carlson… - Trends in biochemical …, 2014 - cell.com
The many biological and biomedical effects of selenium are relatively unknown outside the
selenium field. This fascinating element, initially described as a toxin, was subsequently …

Selenium and iodine deficiencies and selenoprotein function.

JR Arthur, F Nicol, JH Mitchell… - Biomedical and …, 1997 - europepmc.org
This paper reviews some recent findings on the interactions between selenium deficiency
and iodine deficiency. Both micronutrients can control the levels of selenoprotein mRNAs …

Selenoprotein P and selenium distribution in mammals

U Schweizer, L Schomburg, J Köhrle - … : Its molecular biology and role in …, 2016 - Springer
Selenoprotein P (Sepp) is a remarkable selenoprotein. Among all mammalian
selenoproteins, it is the only one containing more than one selenocysteine, and ten in …

Selenoproteins: molecular pathways and physiological roles

VM Labunskyy, DL Hatfield… - Physiological …, 2014 - journals.physiology.org
Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies

M Conrad, U Schweizer - Antioxidants & redox signaling, 2010 - liebertpub.com
Selenium (Se), in the form of the 21st amino acid selenocysteine, is an integral part of
selenoproteins and essential for mammals. While a large number of health claims for Se has …

Selenium: its role as antioxidant in human health

U Tinggi - Environmental health and preventive medicine, 2008 - Springer
Selenium (Se) is an essential trace element, and its low status in humans has been linked to
increased risk of various diseases, such as cancer and heart disease. In recent years, Se …

Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis

RF Burk, KE Hill - Annu. Rev. Nutr., 2005 - annualreviews.org
▪ Abstract Selenoprotein P is an abundant extracellular glycoprotein that is rich in
selenocysteine. It has two domains with respect to selenium content. The N-terminal domain …

Anatomical regional differences in selenium levels in the human brain

P Ramos, A Santos, NR Pinto, R Mendes… - Biological trace element …, 2015 - Springer
The role of selenium in human brain physiology, as well as in aging and neurodegenerative
processes, remains unclear. Thus, the aim of this study was to establish the …

Selenoprotein P and its potential role in Alzheimer's disease

N Solovyev - Hormones, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with
cognitive decline, loss of memory, and progressive cerebral atrophy. The trace element …