Viral vectors play a pivotal role in the field of gene therapy, with several related drugs having
already gained clinical approval from the EMA and FDA. However, numerous viral gene …

Recombinant viral vectors such as adenovirus and adenovirus-associated virus have been
used widely as vehicles for gene therapy applications because of the high efficiency with …

Numerous human genetic and acquired diseases could be corrected or ameliorated if
viruses are harnessed to safely and effectively deliver therapeutic genes to diseased cells …

Gene therapy is a clinical strategy that may potentially treat an array of genetic and
nongenetic diseases, as well as a novel method for drug delivery and vaccination. To these …

Extensively characterized, modified, and employed for a variety of purposes, adenovirus
(Ad) vectors are generally regarded as having great potential by many applied virologists …

Several viral vector-based gene therapy drugs have now received marketing approval. A
much larger number of additional viral vectors are in various stages of clinical trials for the …

Adenoviral (Ad) vectors can efficiently transduce a broad range of cell types and have been
used extensively in preclinical and clinical studies for gene delivery applications. The …

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

Viral vectors have provided effective methods for in vivo gene delivery for therapeutic
purposes. The ability of viruses to infect a wide variety of cell types in vivo has been …

Adenoviruses are the most commonly used vectors for gene therapy. Despite the promising
safety profile demonstrated in clinical trials, the efficacy of using adenoviruses for gene …