Background Cigarette smoke increases the risk of several cardiovascular diseases and has
synergistic detrimental effects when present with other risks that contribute to its …

Background Elevated arginase (Arg) activity is reported to be involved in diabetes-induced
vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …

Abstract Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes
the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was …

Endothelial dysfunction is a hallmark of cardiovascular disease, and the l-arginine: NO
pathway plays a critical role in determining endothelial function. Recent studies suggest that …

L-Arginine (L-arg) is not only the substrate for nitric oxide synthase (NOS) to produce NO,
but also for arginase, which catalyzes conversion L-arg to ornithine and urea. In diabetes …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …