Abstract Development of resistance to platinum compounds significantly hinders successful
ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell …

Ovarian cancer (OVCA) patients often develop tolerance to standard platinum therapy that
accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis‐R) display …

Tumor associated vacuolar H+-ATPases (V-ATPases) are multi-subunit proton pumps that
acidify tumor microenvironment, thereby promoting tumor invasion. Subunit 'a'of its V0 …

Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

In cancer cells, vacuolar ATPase (V-ATPase), a multi-subunit enzyme, is expressed on the
plasma as well as vesicular membranes and critically influences metastatic behavior. The …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Tumor acidity is the key metabolic feature promoting cancer progression and is modulated
by pH regulators on a cancer cell's surface that pump out excess protons/lactic acid for …

Abstract Vacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an
essential role in maintaining intracellular pH homeostasis and a variety of physiological …

Plasma membrane vacuolar H+-ATPase (V-ATPase) activity of tumor cells is a major factor
in control of cytoplasmic and extracellular pH and metastatic potential, but the isoforms …

Abstract Vacuolar ATPases (V‐ATPases) comprise specialized and ubiquitously distributed
pumps that acidify intracellular compartments and energize membranes. To gain new …