Delivery of lethal dsRNAs in insect diets by branched amphiphilic peptide capsules

SM Barros, R Chandrasekar… - The FASEB …, 2019 - Wiley Online Library
Branched Amphiphilic Peptides Capsules (BAPCs™) are a novel class of nano‐carriers
constituted from the spontaneous co‐assembly of two unique, engineered peptide …

Delivery of lethal dsRNAs in insect diets by branched amphiphilic peptide capsules

LA Avila, R Chandrasekar, KE Wilkinson… - Journal of controlled …, 2018 - Elsevier
Abstract Development of new and specific insect pest management methods is critical for
overcoming pesticide resistance and collateral off-target killings. Gene silencing by feeding …

Gene silencing in adult Popillia japonica through feeding of double‐stranded RNA (dsRNA) complexed with branched amphiphilic peptide capsules (BAPCs)

E Carroll, N Kunte, E McGraw, S Gautam… - Frontiers in Insect …, 2023 - frontiersin.org
Gene silencing by feeding double-stranded (dsRNA) holds promise as a novel pest
management strategy. Nonetheless, degradation of dsRNA in the environment and within …

Oral delivery of dsRNA lipoplexes to German cockroach protects dsRNA from degradation and induces RNAi response

YH Lin, JH Huang, Y Liu, X Belles… - Pest management …, 2017 - Wiley Online Library
BACKGROUND In the past years, the concept of RNAi application for insect pest control has
been proposed, considering the disruption of vital genes. However, the efficiency of RNAi is …

Biodegradable drug-delivery peptide nanocapsules

EM Wessel, JM Tomich, RB Todd - ACS omega, 2019 - ACS Publications
Branched amphiphilic peptide capsules (BAPCs) are an efficient transport system that can
deliver nucleic acids, small proteins, and solutes. The ability of BAPCs to break down is …

Liposome encapsulation and EDTA formulation of dsRNA targeting essential genes increase oral RNAi‐caused mortality in the Neotropical stink bug Euschistus heros

NL Castellanos, G Smagghe, R Sharma… - Pest Management …, 2019 - Wiley Online Library
BACKGROUND The Neotropical stink bug Euschistus heros is a major pest in soybean
fields. Development of highly species‐specific pesticides based on RNA interference (RNAi) …

Nano-carrier-based improvement of RNAi efficiency in lepidopteran insects

Z Martinez Reyna - 2022 - biblio.ugent.be
RNA interference (RNAi) is a specific post-transcriptional gene silencing pathway found in
many eukaryotes, including insects. It was first discovered in the nematode Caenorhabditis …

Practical use of RNA interference: oral delivery of double-stranded RNA in liposome carriers for cockroaches

JH Huang, Y Liu, YH Lin, X Belles, HJ Lee - JoVE (Journal of Visualized …, 2018 - jove.com
RNA interference (RNAi) has been widely applied for uncovering the biological functions of
numerous genes, and has been envisaged as a pest control tool operating by disruption of …

Gene delivery and immunomodulatory effects of plasmid DNA associated with Branched Amphiphilic Peptide Capsules

LA Avila, LRMM Aps, N Ploscariu, P Sukthankar… - Journal of Controlled …, 2016 - Elsevier
We recently reported on a new class of branched amphiphilic peptides that associate with
double stranded DNA and promote in vitro transfection of eukaryotic cells. In the present …

Branched amphiphilic cationic oligopeptides form peptiplexes with DNA: a study of their biophysical properties and transfection efficiency

LA Avila, LRMM Aps, P Sukthankar… - Molecular …, 2015 - ACS Publications
Over the past decade, peptides have emerged as a new family of potential carriers in gene
therapy. Peptides are easy to synthesize and quite stable. Additionally, sequences shared …