NF-κB as a therapeutic target in chronic inflammation: recent advances

SS Makarov - Molecular medicine today, 2000 - cell.com
The family of nuclear factor κB (NF-κB) transcription factors is a topic of intense interest in the
biomedical community stemming from the role NF-κB plays in almost every aspect of cell …

NF-κB: arresting a major culprit in cancer

B Haefner - Drug Discovery Today, 2002 - Elsevier
Nuclear factor-κB (NF-κB) has long been known to play a central role in the immune system
by regulating the expression of key genes. Moreover, activation of this transcription factor …

NF‐κB and the link between inflammation and cancer

JA DiDonato, F Mercurio, M Karin - Immunological reviews, 2012 - Wiley Online Library
The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

Y Lin, L Bai, W Chen, S Xu - Expert opinion on therapeutic targets, 2010 - Taylor & Francis
Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-
promoting agents. The reciprocal activation between NF-κB and inflammatory cytokines …

The IKK NF-κB system: a treasure trove for drug development

M Karin, Y Yamamoto, QM Wang - Nature reviews Drug discovery, 2004 - nature.com
Nuclear factor-κB (NF-κB)/Rel transcription factors have been suspected since their
discovery to play a pivotal role in chronic and acute inflammatory diseases. It now seems …

The diverse and complex roles of NF-κB subunits in cancer

ND Perkins - Nature Reviews Cancer, 2012 - nature.com
It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer
development has been understood. Although much attention has focused on the upstream …

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

ET Wong, V Tergaonkar - Clinical science, 2009 - portlandpress.com
The NF-κB (nuclear factor κB) family of transcription factors are involved in a myriad of
activities, including the regulation of immune responses, maturation of immune cells …

[HTML][HTML] NF-κB signaling in inflammation

T Liu, L Zhang, D Joo, SC Sun - Signal transduction and targeted …, 2017 - nature.com
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …

[HTML][HTML] Transcriptional regulation during aberrant activation of NF-κB signalling in cancer

K Deka, Y Li - Cells, 2023 - mdpi.com
The NF-κB signalling pathway is a major signalling cascade involved in the regulation of
inflammation and innate immunity. It is also increasingly recognised as a crucial player in …

NF-κB as a critical link between inflammation and cancer

M Karin - Cold Spring Harbor perspectives in biology, 2009 - cshperspectives.cshlp.org
NF-κB transcription factors have been suspected to be involved in cancer development
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …