NF‐κB is a generic name for an evolutionarily conserved transcription‐factor system that
contributes to the mounting of an effective immune response but is also involved in the …

IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of
physiological and pathological processes. One function of NF-κB is promotion of cell survival …

Two members of the NF-κB (nuclear factor κB)/Rel transcription factor family, NF-κB1 and NF-
κB2, are produced as precursor proteins, NF-κB1 p105 and NF-κB2 p100 respectively …

Inflammation, when properly mounted and precisely calibrated, is a beneficial process that
enables the rapid removal of invading pathogens and/or cellular corpses and promotes …

The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

Immune system activation is essential to thwart the invasion of pathogens and respond
appropriately to tissue damage. However, uncontrolled inflammation can result in extensive …

Numerous lines of investigation suggest that nuclear factor NF-κB, a proinflammatory
transcription factor, could promote tumorigenesis. Various inflammatory agents …

There is growing evidence for a connection between inflammation and tumor development,
and the nuclear factor kappa B (NF-κB), a proinflammatory transcription factor, is …