Advances in the research of cytokine storm mechanism induced by Corona Virus Disease 2019 and the corresponding immunotherapies

C Chen, X ZHANG, Z JU, W HE - Chinese journal of burns, 2020 - pesquisa.bvsalud.org
ABSTRACT Corona Virus Disease 2019 (COVID-19) has seriously affected the treatment of
patients and social stability. In the later stage of disease, some COVID-19 patients may …

Contribution of STAT3 to the pathogenesis of COVID-19

A Jafarzadeh, M Nemati, S Jafarzadeh - Microbial pathogenesis, 2021 - Elsevier
Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine
storm, large viral replication and massive cell death play fundamental roles in the …

SARS‐CoV‐2 NSP8 suppresses type I and III IFN responses by modulating the RIG‐I/MDA5, TRIF, and STING signaling pathways

J Deng, SN Zheng, Y Xiao, ML Nan… - Journal of Medical …, 2023 - Wiley Online Library
SARS‐CoV‐2 has developed a variety of approaches to counteract host innate antiviral
immunity to facilitate its infection, replication and pathogenesis, but the molecular …

[HTML][HTML] Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2

Z Yao, Z Zheng, K Wu, Z Junhua - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Currently, we are on a global pandemic of Coronavirus disease-2019 (COVID-19) which
causes fever, dry cough, fatigue and acute respiratory distress syndrome (ARDS) that may …

Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z Xie, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients

S Mantovani, S Daga, C Fallerini, M Baldassarri… - Genes & …, 2022 - nature.com
Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses
to a variety of pathogens, triggering the production of pro-inflammatory cytokines and type I …

SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions

P Asrani, MI Hassan - Molecular and Cellular Biochemistry, 2021 - Springer
The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-
CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

A Attiq, LJ Yao, S Afzal, MA Khan - International immunopharmacology, 2021 - Elsevier
Abstract The coronavirus disease (COVID-19) has once again reminded us of the
significance of host immune response and consequential havocs of the immune …

Cytokine storm signature in patients with moderate and severe COVID-19

O Kalinina, A Golovkin, E Zaikova, A Aquino… - International Journal of …, 2022 - mdpi.com
Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ
dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was …