Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits
We developed a likelihood-based approach for analyzing summary-level statistics and
external linkage disequilibrium information to estimate effect-size distributions of common …
external linkage disequilibrium information to estimate effect-size distributions of common …
Molecular genetics in psychology and personality neuroscience: On candidate genes, genome wide scans, and new research strategies
Despite the substantial heritability estimates for psychological traits, their precise genetic
foundation from a molecular perspective remains elusive. We summarize findings and …
foundation from a molecular perspective remains elusive. We summarize findings and …
Progress and promise of genome-wide association studies for human complex trait genetics
Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …
There has been early success for prevalent diseases with complex phenotypes. These …
Interpreting population-and family-based genome-wide association studies in the presence of confounding
A central aim of genome-wide association studies (GWASs) is to estimate direct genetic
effects: the causal effects on an individual's phenotype of the alleles that they carry …
effects: the causal effects on an individual's phenotype of the alleles that they carry …
A dynamic model for genome-wide association studies
Although genome-wide association studies (GWAS) are widely used to identify the genetic
and environmental etiology of a trait, several key issues related to their statistical power and …
and environmental etiology of a trait, several key issues related to their statistical power and …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …
the biology of complex traits, drug development and clinical guidelines. However, the …
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
Replicable genetic association signals have consistently been found through genome-wide
association studies in recent years. The recent dramatic expansion of study sizes improves …
association studies in recent years. The recent dramatic expansion of study sizes improves …
Phenotypic annotation: using polygenic scores to translate discoveries from genome-wide association studies from the top down
Genome-wide association studies (GWASs) have identified specific genetic variants
associated with complex human traits and behaviors, such as educational attainment …
associated with complex human traits and behaviors, such as educational attainment …
Genetic variation in the social environment contributes to health and disease
Assessing the impact of the social environment on health and disease is challenging. As
social effects are in part determined by the genetic makeup of social partners, they can be …
social effects are in part determined by the genetic makeup of social partners, they can be …
A tutorial on conducting genome‐wide association studies: Quality control and statistical analysis
AT Marees, H de Kluiver, S Stringer… - … journal of methods …, 2018 - Wiley Online Library
Objectives Genome‐wide association studies (GWAS) have become increasingly popular to
identify associations between single nucleotide polymorphisms (SNPs) and phenotypic …
identify associations between single nucleotide polymorphisms (SNPs) and phenotypic …