Background Wolfram syndrome (WS), a rare genetic disorder, is considered the best
prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood …

Wolfram syndrome 1 (WS1) is a rare neurodegenerative disease transmitted in an
autosomal recessive mode. It is characterized by diabetes insipidus (DI), diabetes mellitus …

Rigoli L, Lombardo F, Di Bella C. Wolfram syndrome and WFS1 gene. Wolfram syndrome
(WS)(MIM 222300) is a rare multisystem neurodegenerative disorder of autosomal recessive …

Abstract Background Wolfram Syndrome (WFS: OMIM 222300) is an autosomal recessive,
progressive, neurologic and endocrinologic degenerative disorder caused by mutations in …

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes
mellitus, diabetes insipidus, optic nerve atrophy, hearing loss, and neurodegeneration …

Objective Wolfram syndrome (WS) is a rare neurodegenerative disorder characterized by
juvenile‐onset diabetes mellitus and optic atrophy. Our aim was to describe the nature and …

Purpose Wolfram syndrome is a degenerative, recessive rare disease with an onset in
childhood. It is caused by mutations in WFS1 or CISD2 genes. More than 200 different …

Abstract Wolfram syndrome 1 (WS1) is a rare autosomal recessive neurodegenerative
disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and …

Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disease mainly
characterized by familial diabetes mellitus and optic atrophy. WS patients frequently present …

Wolfram Syndrome (WFS) is a rare autosomal recessive disease characterized by insulin-
dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, deafness, and …