The epidermal growth factor receptor (EGFR) located in dorsal root ganglion has been found
as a new target for chronic pain treatment. However, it is not clear whether the change of …

Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …

Neuropathic pain (NP) is caused by primary or secondary impairment of the peripheral or
central nervous systems. Its etiology is complex and involves abnormal patterns of gene …

Neuropathic pain is one of the important challenges in the clinic. Although a lot of research
has been done on neuropathic pain (NP), the molecular mechanism is still elusive. We …

Chemokines and their receptors have been demonstrated to be important contributors to the
development and maintenance of chronic pain. Recent studies showed that chemokine …

Some individuals recover from the pain of nerve trauma within 12 months or less whereas
others experience life-long intractable pain. This transition between reversible pain and the …

In tumor cells, interleukin-6 (IL-6) signaling can lead to activation of the epidermal growth
factor receptor (EGFR), which prolongs Stat3 activation. In the present experiments, we …

Although microglia activation plays an important role in the development of nerve injury-
induced neuropathic pain, the molecular mechanisms of spinal cord microglia activation in …

Injury or inflammation affecting sensory neurons in the dorsal root ganglia (DRG) causes
hyperexcitability of DRG neurons that can lead to spinal central sensitization and …

Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here,
we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root …