Neuroinflammation and Alzheimer's disease: a machine learning approach to CSF proteomics
L Gaetani, G Bellomo, L Parnetti, K Blennow… - Cells, 2021 - mdpi.com
In Alzheimer's disease (AD), the contribution of pathophysiological mechanisms other than
amyloidosis and tauopathy is now widely recognized, although not clearly quantifiable by …
amyloidosis and tauopathy is now widely recognized, although not clearly quantifiable by …
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
In advanced age, some individuals maintain a stable cognitive trajectory while others
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease
An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
Pulse-chase proteomics of the App knockin mouse models of Alzheimer's disease reveals that synaptic dysfunction originates in presynaptic terminals
TJ Hark, NR Rao, C Castillon, T Basta, S Smukowski… - Cell systems, 2021 - cell.com
Compromised protein homeostasis underlies accumulation of plaques and tangles in
Alzheimer's disease (AD). To observe protein turnover at early stages of amyloid beta (Aβ) …
Alzheimer's disease (AD). To observe protein turnover at early stages of amyloid beta (Aβ) …
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations
JM Ringman, H Schulman, C Becker… - Archives of …, 2012 - jamanetwork.com
Objective To identify cerebrospinal fluid (CSF) protein changes in persons who will develop
familial Alzheimer disease (FAD) due to PSEN1 and APP mutations, using unbiased …
familial Alzheimer disease (FAD) due to PSEN1 and APP mutations, using unbiased …
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Despite recent advances in fluid biomarker research in Alzheimer's disease (AD), there are
no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available …
no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available …
Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …