To investigate the intracellular signal transduction pathways involved in the
pathophysiological mechanisms of neuropathic pain after partial nerve injury, we examined …

To investigate whether activation of mitogen-activated protein kinase (MAPK) in damaged
and/or undamaged primary afferents participates in neuropathic pain after partial nerve …

Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …

Recent work regarding chronic central neuropathic pain (CNP) following spinal cord injury
(SCI) suggests that activation of key signaling molecules such as members of the mitogen …

The activation of glial cells in the CNS has been suggested to be involved in abnormal pain
sensation after peripheral nerve injury. Previous studies demonstrated phosphorylation of …

Nerve injury elicits both universal and limited responses. Among the former is regenerative
growth, which occurs in most peripheral neurons, and among the latter is the long-term …

Background Intense nociceptive signaling arising from ongoing injury activates primary
afferent nociceptive systems to generate peripheral sensitization. ERK1/2 phosphorylation in …

Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein)
kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation …

Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …

BACKGROUND: The phosphorylation of p38 mitogen-activated protein kinase (MAPK) in the
dorsal root ganglion (DRG) promotes primary afferent sensitization. The role of p38MAPK …