S-sulfhydration as a cellular redox regulation

M Iciek, D Kowalczyk-Pachel, A Bilska-Wilkosz… - Bioscience …, 2016 - portlandpress.com
For many years reactive oxygen and nitrogen species (ROS and RNS) have been
recognized as key messengers in the process of thiol-based redox regulation. Relatively …

Biological hydropersulfides and related polysulfides–a new concept and perspective in redox biology

JM Fukuto, LJ Ignarro, P Nagy, DA Wink, CG Kevil… - FEBS …, 2018 - Wiley Online Library
The chemical biology of thiols (RSH, eg, cysteine and cysteine‐containing
proteins/peptides) has been a topic of extreme interest for many decades due to their …

The biological/physiological utility of hydropersulfides (RSSH) and related species: What is old is new again

JM Fukuto - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: Hydrogen sulfide (H2S) is reported to be an important mediator involved in
numerous physiological processes. H2S and hydropersulfides (RSSH) species are …

Fluorescent probes and selective inhibitors for biological studies of hydrogen sulfide-and polysulfide-mediated signaling

Y Takano, H Echizen, K Hanaoka - Antioxidants & redox signaling, 2017 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) plays roles in many physiological processes,
including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition …

The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems

CL Bianco, T Akaike, T Ida, P Nagy… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose The signalling associated with hydrogen sulfide (H2S) remains to
be established, and recent studies have alluded to the possibility that H2S‐derived species …

Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

R Wedmann, C Onderka, S Wei, IA Szijártó… - Chemical …, 2016 - pubs.rsc.org
Hydrogen sulfide (H2S) has emerged as a signalling molecule capable of regulating several
important physiological functions such as blood pressure, neurotransmission and …

Hydrogen sulfide and persulfides oxidation by biologically relevant oxidizing species

D Benchoam, E Cuevasanta, MN Möller, B Alvarez - Antioxidants, 2019 - mdpi.com
Hydrogen sulfide (H2S/HS–) can be formed in mammalian tissues and exert physiological
effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) …

Redox signaling regulated by cysteine persulfide and protein polysulfidation

S Kasamatsu, A Nishimura, M Morita, T Matsunaga… - Molecules, 2016 - mdpi.com
For decades, reactive persulfide species including cysteine persulfide (CysSSH) have been
known to exist endogenously in organisms. However, the physiological significance of …

Development of hydropersulfide donors to study their chemical biology

VS Khodade, SC Aggarwal, A Eremiev… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: Hydropersulfides (RSSH) are ubiquitous in prokaryotes, eukaryotic cells, and
mammalian tissues. The unique chemical properties and prevalent nature of these species …

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility

K Ono, T Akaike, T Sawa, Y Kumagai, DA Wink… - Free Radical Biology …, 2014 - Elsevier
Hydrogen sulfide (H 2 S) is an endogenously generated and putative signaling/effector
molecule. Despite its numerous reported functions, the chemistry by which it elicits its …