Glymphatic system a window on TBI pathophysiology: a systematic review

M Ferrara, G Bertozzi, G Volonnino, N Di Fazio… - International Journal of …, 2022 - mdpi.com
Background: In recent years, the attention of the scientific world has focused on a clearance
system of brain waste metabolites, called the glymphatic system, based on its similarity to …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

Glymphatic system in the central nervous system, a novel therapeutic direction against brain edema after stroke

X Zhou, Y Li, C Lenahan, Y Ou, M Wang… - Frontiers in Aging …, 2021 - frontiersin.org
Stroke is the destruction of brain function and structure, and is caused by either
cerebrovascular obstruction or rupture. It is a disease associated with high mortality and …

The glymphatic system for neurosurgeons: a scoping review

M Al Masri, A Corell, I Michaëlsson, AS Jakola… - Neurosurgical …, 2024 - Springer
The discovery of the glymphatic system has revolutionized our understanding of
cerebrospinal fluid (CSF) circulation and interstitial waste clearance in the brain. This …

The role of glymphatic system in the cerebral edema formation after ischemic stroke

C Ji, X Yu, W Xu, C Lenahan, S Tu, A Shao - Experimental Neurology, 2021 - Elsevier
Cerebral edema following ischemic stroke is predictive of the severity of the eventual stroke
related damage, however the effective treatment is limited. The glymphatic system is a …

Cerebral edema formation after stroke: emphasis on blood–brain barrier and the lymphatic drainage system of the brain

S Chen, L Shao, L Ma - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Brain edema is a severe stroke complication that is associated with prolonged
hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral …

Glymphatic system as a gateway to connect neurodegeneration from periphery to CNS

G Natale, F Limanaqi, CL Busceti… - Frontiers in …, 2021 - frontiersin.org
The classic concept of the absence of lymphatic vessels in the central nervous system
(CNS), suggesting the immune privilege of the brain in spite of its high metabolic rate, was …

Glymphatic Drainage Blocking Aggravates Brain Edema, Neuroinflammation via Modulating TNF-α, IL-10, and AQP4 After Intracerebral Hemorrhage in Rats

X Liu, G Wu, N Tang, L Li, C Liu, F Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
Objective: The “Glymphatic” system, a network of perivascular tunnels wrapped by astrocyte
endfeet, was reported to be closely associated with the diseases of the central nervous …

Glymphatic system pathology and neuroinflammation as two risk factors of neurodegeneration

S Szlufik, K Kopeć, S Szleszkowski, D Koziorowski - Cells, 2024 - mdpi.com
The key to the effective treatment of neurodegenerative disorders is a thorough
understanding of their pathomechanism. Neurodegeneration and neuroinflammation are …

Glymphatic system: an emerging therapeutic approach for neurological disorders

Y Gao, K Liu, J Zhu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The functions of the glymphatic system include clearance of the metabolic waste and
modulation of the water transport in the brain, and it forms a brain-wide fluid network along …