Background SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is
overexpressed in some solid tumors, and is expressed in epithelial cells of the lung …

Recently, the SOX2 gene has been reported to be amplified in human lung squamous cell
carcinomas. However, its roles in human lung adenocarcinomas are still elusive. In this …

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene
amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as …

SOX2 is a stem cell transcription factor that plays a crucial role in the regulation of embryonic
development. It is one of the genes in a set of factors (Oct4, SOX2, Nanog) that are able to …

The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the
mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of …

Background: The cancer stem cell hypothesis suggests that neoplastic clones are
maintained exclusively by a small subpopulation of cells, which have indefinite proliferation …

Sox2 is a transcription factor that regulates embryonic stem cell pluripotency and drives
commitment of airway precursor cells to basal-type and neuroendocrine cells in the …

Recent studies demonstrated that cancer stem cells (CSCs) have higher tumorigenesis
properties than those of differentiated cancer cells and that transcriptional factor-SOX2 plays …

Tumor cells have long been observed to share several biological characteristics with normal
stem/progenitor cells; however, the oncogenic mechanisms underlying the lung …

The transcription factor SOX2 (3q26. 3–q27) is a key regulator of foregut development and
an embryonic stem cell factor cooperating during induction of pluripotency in terminally …