Introduction Fungi biosynthesize chemically diverse secondary metabolites with a wide
range of biological activities. Natural product scientists have increasingly turned towards …

Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Natural products research increasingly applies-omics technologies to guide molecular
discovery. While the combined analysis of genomic and metabolomic datasets has proved …

Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …

Recent advancements in genome sequencing and bioinformatic analysis of fungal genomes
have revealed that fungi possess cryptic or silent biosynthetic gene clusters (BGCs). This …

Fungal secondary metabolites (SMs) represent an invaluable source of therapeutic drugs.
Genomics-based approaches to SM discovery have revealed a vast and largely untapped …

Fungi are well known as prolific sources of unique and diverse bioactive natural products.
Many members of commonly occurring fungal genera have been extensively surveyed, and …

One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

Filamentous fungi possess great potential as sources of medicinal bioactive compounds,
such as antibiotics, but efficient production is hampered by a limited understanding of how …