[HTML][HTML] Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

DN Streblow, AJ Hirsch, JJ Stanton, AD Lewis… - Nature …, 2023 - nature.com
Passively administered monoclonal antibodies (mAbs) given before or after viral infection
can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to …

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, there remains a need for more prevention and treatment options for individuals …

[HTML][HTML] The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential …

CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-
19, little is known about their mechanism (s) of action or effective dosing windows. We report …

[HTML][HTML] Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in …

KKA Van Rompay, KJ Olstad, RL Sammak… - PLoS …, 2021 - journals.plos.org
There is an urgent need for effective therapeutic interventions against SARS-CoV-2,
including new variants that continue to arise. Neutralizing monoclonal antibodies have …

[HTML][HTML] The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization

A Zebardast, P Hosseini, A Hasanzadeh… - Molecular Biology …, 2022 - Springer
The severe acute respiratory syndrome (SARS-CoV-2), a newly emerging of coronavirus,
continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that …

[HTML][HTML] A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection

W Tai, K Yang, Y Liu, R Li, S Feng, B Chai… - Nature …, 2023 - nature.com
The respiratory system, especially the lung, is the key site of pathological injury induced by
SARS-CoV-2 infection. Given the low feasibility of targeted delivery of antibodies into the …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed.
Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led …

[HTML][HTML] A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

X Zhang, H Zhang, T Li, S Chen, F Luo… - Signal transduction and …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still rapidly spreading
worldwide. Many drugs and vaccines have been approved for clinical use show efficacy in …

Potent neutralization of SARS‐CoV‐2 including variants of concern by vaccines presenting the receptor‐binding domain multivalently from nanoscaffolds

PJ Halfmann, A Castro, K Loeffler… - Bioengineering & …, 2021 - Wiley Online Library
The persistence of the global severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
2) pandemic has brought to the forefront the need for safe and effective vaccination …

Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutralization

D Li, T Li, H Cai, H Yao, B Zhou, Y Zhao, W Qin… - 2020 - pesquisa.bvsalud.org
ABSTRACT SARS-CoV-2, the causative agent of COVID-191, recognizes host cells by
attaching its receptor-binding domain (RBD) to the host receptor ACE22-7. Neutralizing …