N6-methyladenosine reader YTHDF3 contributes to the aerobic glycolysis of osteosarcoma through stabilizing PGK1 stability
D Liu, Z Li, K Zhang, D Lu, D Zhou, Y Meng - Journal of Cancer Research …, 2023 - Springer
Abstract Purpose N6-methyladenosine (m6A) modification is a pivotal transcript chemical
modification of eukaryotics, which has been identified to play critical roles on tumor …
modification of eukaryotics, which has been identified to play critical roles on tumor …
M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression
D Lv, S Ding, L Zhong, J Tu, H Li, H Yao, Y Zou, Z Zeng… - Oncogene, 2022 - nature.com
Despite advances in clinical diagnosis and treatment, the prognosis of patients with
osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is …
osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is …
[HTML][HTML] ELK1-mediated YTHDF1 drives prostate cancer progression by facilitating the translation of Polo-like kinase 1 in an m6A dependent manner
P Li, Y Shi, D Gao, H Xu, Y Zou, Z Wang… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background: N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications
in mammals, and it regulates the fate of modified RNA transcripts. In the current study, we …
in mammals, and it regulates the fate of modified RNA transcripts. In the current study, we …
Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by …
S Li, L Cao - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N6-Methyladenosine (m6A) is the most abundant modifications in human
messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism …
messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism …
[HTML][HTML] ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma
S Chen, L Zhou, Y Wang - Cancer cell international, 2020 - Springer
Background Osteosarcoma (OS) is one of the most common malignant bone tumors.
Plasmacytoma variant translocation 1 (PVT1) is a well-known oncogenic long noncoding …
Plasmacytoma variant translocation 1 (PVT1) is a well-known oncogenic long noncoding …
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels
K Zhu, Y Li, Y Xu - Life Sciences, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A) is the most frequent posttranscriptional
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
[HTML][HTML] N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
L Zou, W Chen, X Zhou, T Yang, J Luo, Z Long… - Cell Death …, 2022 - nature.com
The fat mass and obesity-associated protein (FTO) is an N6-Methyladenosine (m6A)
demethylase, which has been revealed to play critical roles in tumorigenesis. However, its …
demethylase, which has been revealed to play critical roles in tumorigenesis. However, its …
METTL3 upregulates COPS5 expression in osteosarcoma in an m6A-related manner to promote osteosarcoma progression
C Zhang, J Wan, Q Liu, F Long, Z Wen, Y Liu - Experimental Cell Research, 2022 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most abundant and well-studied internal
modification of messenger RNAs (mRNAs). Although m 6 A mRNA modification has been …
modification of messenger RNAs (mRNAs). Although m 6 A mRNA modification has been …
FTO regulates myoblast proliferation by controlling CCND1 expression in an m6A-YTHDF2-dependent manner
K Deng, Z Zhang, C Ren, Y Liang, X Gao, Y Fan… - Experimental Cell …, 2021 - Elsevier
Abstract N6-Methyladenosine (m 6 A) modification is the most abundant chemical
modification in mRNA, and it participates in various biological processes, such as cell …
modification in mRNA, and it participates in various biological processes, such as cell …
[HTML][HTML] YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma
Y Bai, C Yang, R Wu, L Huang, S Song, W Li… - Frontiers in …, 2019 - frontiersin.org
YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in RNA
methylation modification. Recent studies have shown that m6A is closely related to multiple …
methylation modification. Recent studies have shown that m6A is closely related to multiple …