[HTML][HTML] Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression

L Zhang, L Zhang, X Xia, S He, H He, W Zhao - Oncotarget, 2016 - ncbi.nlm.nih.gov
Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, is an essential regulator in
many cellular processes, including differentiation, proliferation, inflammation, pluripotency …

[HTML][HTML] m6A-dependent upregulation of TRAF6 by METTL3 is associated with metastatic osteosarcoma

J Wang, W Wang, X Huang, J Cao, S Hou, X Ni… - Journal of Bone …, 2022 - Elsevier
Objectives RNA N6-methyladenosine (m6A) is associated with tumorigenesis. The
importance of methyltransferase-like 3 (METTL3) has been reported in cancer progression …

Identification and validation of the N6-methyladenosine RNA methylation regulator YTHDF1 as a novel prognostic marker and potential target for hepatocellular …

S Bian, W Ni, M Zhu, Q Song, J Zhang, R Ni… - Frontiers in molecular …, 2020 - frontiersin.org
Purpose: N6-methyladenosine (m6A) RNA methylation has been implicated in various
malignancies. This study aimed to identify the m6A methylation regulator-based prognostic …

RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma

Y Cui, C Zhang, S Ma, Z Li, W Wang, Y Li, Y Ma… - Journal of Experimental …, 2021 - Springer
Background Long non-coding RNA (LncRNA) controls cell proliferation and plays a
significant role in the initiation and progression of esophageal squamous cell carcinoma …

[HTML][HTML] N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

Q Wu, X Xie, Y Huang, S Meng, Y Li, H Wang… - Journal of …, 2021 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is one of the most common epithelial malignant tumors and the fifth
leading cause of cancer death in men. An increasing number of studies have demonstrated …

RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent …

Z Tan, S Shi, J Xu, X Liu, Y Lei, B Zhang, J Hua… - Oncogene, 2022 - nature.com
Abstract RNA N6-methyladenosine (m6A) is an emerging regulator of mRNA modifications
and represents a novel player in tumorigenesis. Although it has functional significance in …

Silencing of lncRNA KLF3‐AS1 represses cell growth in osteosarcoma via miR‐338‐3p/MEF2C axis

C Chen, L Liu - Journal of Clinical Laboratory Analysis, 2022 - Wiley Online Library
Background Osteosarcoma (OS) is a highly recurrent malignancy occurring among
adolescents. The goal of this research was to scrutinize the role and action mechanism of …

Oxidative stress-induced hypermethylation of KLF5 promoter mediated by DNMT3B impairs osteogenesis by diminishing the interaction with β-catenin

L Li, H Wang, X Chen, X Li, G Wang, Z Jie… - Antioxidants & redox …, 2021 - liebertpub.com
Aims: Emerging evidence suggests that the pathogenesis of osteoporosis, characterized by
impaired osteogenesis, is shifting from estrogen centric to oxidative stress. Our previous …

Knockdown of 91 H suppresses the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter

S Cheng, J Zheng, X Liu, J Shi, F Gong… - … in Cancer Research …, 2021 - journals.sagepub.com
Background: Osteosarcoma is the most leading primary malignancy of the bone in
adolescents all over the world. Long non-coding RNA (lncRNA) 91 H has been reported to …

FTO prevents thyroid cancer progression by SLC7A11 m6A methylation in a ferroptosis-dependent manner

FH Ji, XH Fu, GQ Li, Q He, XG Qiu - Frontiers in Endocrinology, 2022 - frontiersin.org
N6 methyladenosine (m6A) modification serves as a novel epigenetic regulatory mechanism
that is heavily implicated in the heredity of tumors. Meanwhile, fat mass and obesity …