Osteosarcoma (OS) is one of the most common types of primary bone tumors in early
adolescence with unsatisfied prognosis. Aberrant DNA methylation had been demonstrated …

Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …

As a systemic disease, osteoporosis (OP) results in bone density loss and fracture risk,
particularly in the hip and vertebrae. However, the underlying molecular mechanisms of OP …

ALKBH5 is the main enzyme for m6A-based demethylation of RNAs and it has been
implicated in many biological and pathophysiological processes. Here, we aimed to explore …

Abstract tRNA-derived fragments (tRFs) are a class of regulatory non-coding RNAs that play
essential biological functions in cancer and stress-induced diseases. Several lines of …

Abstract Background N6-methyladenosine (m6A) is the most abundant reversible
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …

Background Osteosarcoma is a disease with high mortality in children and adolescents, and
metastasis is one of the important clinical features of osteosarcoma. N 6-Methyladenosine …

Abstract RNA N6‐methyladenosine (m6A) is an emerging regulatory mechanism for tumor
progression in several types of cancer. However, the underlying regulation mechanisms of …

Purpose Osteosarcoma (OS) is one of the most prevalent primary malignant bone tumors in
adolescent. HOTAIR is highly expressed and associated with the epigenetic modifications …

Liver cancer is the fourth leading cause of cancer‑associated mortality worldwide. Statistics
indicate that the incidence of liver cancer has been increasing and that its prognosis …