[HTML][HTML] The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation
Y Yuan, Y Du, L Wang, X Liu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is the richest modification in mammalian messenger
RNAs (mRNAs), and exerts key roles in many biological processes, including cancer …
RNAs (mRNAs), and exerts key roles in many biological processes, including cancer …
The RNA N6-methyladenosine demethylase FTO promotes head and neck squamous cell carcinoma proliferation and migration by increasing CTNNB1
Y Zhang, L Chen, X Wu, Z Sun, F Wang… - … Journal of General …, 2021 - Taylor & Francis
Objective In this study, we aimed to investigate the role of RNA N6-methyladenosine
demethylase fat mass and obesity-associated protein (FTO) in head and neck squamous …
demethylase fat mass and obesity-associated protein (FTO) in head and neck squamous …
[HTML][HTML] Depletion of the m6A demethylases FTO and ALKBH5 impairs growth and metastatic capacity through EMT phenotype change in clear cell renal cell …
W Hu, N Klümper, D Schmidt, M Ritter… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Background: N 6-methyladenosine (m 6 A) is one of the most common RNA modifications in
eukaryotes and has effects on RNA structure and stability. Recent studies have shown that …
eukaryotes and has effects on RNA structure and stability. Recent studies have shown that …
ALKBH5‐mediated m6A modification of lncRNA KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9
Y Li, B Yan, X Wang, Q Li, X Kan… - Journal of Cellular …, 2022 - Wiley Online Library
It has been shown that N6‐methyladenosine (m6A) modification is involved in the
development of complex human diseases, especially in the development of cancer. Our …
development of complex human diseases, especially in the development of cancer. Our …
METTL3 mediated MALAT1 m6A modification promotes proliferation and metastasis in osteosarcoma cells
Y Zhang, Y Xu, G Qiu, Y Luo, Y Bao, J Lu, T Wang… - Molecular …, 2023 - Springer
Background As one of the most ubiquitous types of posttranscriptional modification, N6-
methyladenosine (m6A) is extensively implicated in almost all types of cancers, including …
methyladenosine (m6A) is extensively implicated in almost all types of cancers, including …
[HTML][HTML] RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways
J Qu, Y Hou, Q Chen, J Chen, Y Li, E Zhang, H Gu… - Oncogene, 2022 - nature.com
Abstract N6-methyladenosine (m6A), an internal modification in mRNA, plays a critical role
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …
[HTML][HTML] ALKBH5 inhibits pancreatic cancer motility by decreasing long non-coding RNA KCNK15-AS1 methylation
Background/Aims: Mounting evidence suggests that epitranscriptional modifications
regulate multiple cellular processes. N 6-Methyladenosine (m 6 A), the most abundant …
regulate multiple cellular processes. N 6-Methyladenosine (m 6 A), the most abundant …
[HTML][HTML] FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer
L Gao, A Wang, Y Chen, X Cai, Y Li, J Zhao… - Cell Communication and …, 2023 - Springer
Background Emerging evidence suggests the critical roles of N6-methyladenosine (m6A)
RNA modification in tumorigenesis and tumor progression. However, the role of m6A in non …
RNA modification in tumorigenesis and tumor progression. However, the role of m6A in non …
METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2
FC Huo, ZM Zhu, WT Zhu, QY Du, J Liang, J Mou - Oncogene, 2021 - nature.com
Abstract N6-methyladenosine (m6A) RNA methylation is profoundly involved in epigenetic
regulation, especially for carcinogenesis and tumor progression. Mounting evidence …
regulation, especially for carcinogenesis and tumor progression. Mounting evidence …
[HTML][HTML] RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68
Q Nie, X Wu, Y Huang, T Guo, J Kuang… - European Journal of …, 2023 - Springer
Purpose There is no report about the direct relationship between m6A modification and
androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the …
androgen receptor (AR)-related genes in prostate cancer (PC). We aimed to study the …