N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation

Z Zhang, L Wang, L Zhao, Q Wang… - Clinical and …, 2022 - Wiley Online Library
Background As the most widespread mRNAs modification, N6‐methyladenosine (m6A) is
dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is …

METTL3-mediated LINC00657 promotes osteogenic differentiation of mesenchymal stem cells via miR-144-3p/BMPR1B axis

J Peng, Y Zhan, Y Zong - Cell and Tissue Research, 2022 - Springer
Abstract N6-methyladenosine (m6A) modification plays a crucial role in the progression of
osteoporosis (OP). The study aimed to explore the effects of methyltransferase-like 3 …

[HTML][HTML] KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma

Y Jiang, F Li, B Gao, M Ma, M Chen, Y Wu, W Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Rationale: Osteosarcoma (OS), the most common type of bone tumor, which
seriously affects the patients' limb function and life quality. OS has a strong tendency of lung …

FTO demethylates YAP mRNA promoting oral squamous cell carcinoma tumorigenesis.

LI Dian-Qi, CC Huang, G Zhang, Z Lei-Lei - Neoplasma, 2022 - search.ebscohost.com
Abstract N6-methyladenosine (m< sup> 6</sup> A) is the most common internal reversible
modification of mRNA, which occurs on the N< sup> 6</sup> nitrogen of adenosine. Fat …

FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway

L Zhang, Y Wan, Z Zhang, Y Jiang, J Lang, W Cheng… - RNA biology, 2021 - Taylor & Francis
Although many studies have confirmed the relationship between obesity and endometrial
cancer (EC), the molecular mechanism between obesity and EC progression has not been …

M6A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling

JQ Chen, YP Tao, YG Hong, HF Li, ZP Huang, XF Xu… - Cell Cycle, 2021 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) modification, the most abundant internal
methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. There is …

The FTO mediated N6-methyladenosine modification of DDIT4 regulation with tumorigenesis and metastasis in prostate cancer

Y Zhao, X Hu, H Yu, H Sun, L Zhang, C Shao - Research, 2024 - spj.science.org
The progression of numerous malignancies has been linked to N6-methyladenosine (m6A)
alteration. However, the opposite trend of m6A levels in the development and metastasis of …

Long noncoding RNA KCNQ1OT1 contributes to tumor growth and activates Wnt/β‑catenin signaling in osteosarcoma by targeting the miR‑3666/KLF7 axis

A Huang, S Jin, W Han, Y Wang… - International …, 2021 - spandidos-publications.com
Osteosarcoma (OS) is a type of primary malignant cancer occurring in the bone and poses a
threat to the lives of children and young adults. Long non‑coding RNAs (lncRNAs) have …

Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma

J Jiang, Q Fan, H Qu, C Liu, T Liang, L Chen… - Scientific Reports, 2022 - nature.com
Ewing's sarcoma has a poor prognosis and high metastasis rate; thus, it is critical to explore
prognostic biomarkers of m6A-related genes. Two datasets were downloaded from the Gene …

M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma

M He, Y Wang, J Xie, J Pu, Z Shen, A Wang, T Li… - Oncogene, 2024 - nature.com
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but
resistance to chemotherapy limits its curative effect. Here, we have identified that METTL1 …