Heat shock protein expression and autophagy after incomplete thermal ablation and their correlation

F Chen, H Bao, H Xie, G Tian… - International Journal of …, 2019 - Taylor & Francis
Objective: To establish a model of incomplete ablation in nude mice with hepatocellular
carcinoma (HCC) and to evaluate heat shock protein (HSP) expression and autophagy and …

Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation

F Chen, H Xie, H Bao, L Violetta… - Molecular Medicine …, 2020 - spandidos-publications.com
The present study evaluated the effect of combining inhibitors (17‑AAG) of heat shock
protein 90 (HSP90) and autophagy (3‑MA) on apoptosis using an incomplete thermal …

[HTML][HTML] Heat shock increases levels of reactive oxygen species, autophagy and apoptosis

S Kassis, M Grondin, DA Averill-Bates - Biochimica et Biophysica Acta (BBA …, 2021 - Elsevier
Hyperthermia is a promising anticancer treatment used in combination with radiotherapy
and chemotherapy. Temperatures above 41.5° C are cytotoxic and hyperthermia treatments …

Expression of heat shock proteins in human hepatocellular carcinoma after radiofrequency ablation in an animal model

G Schueller, J Kettenbach, R Sedivy… - Oncology …, 2004 - spandidos-publications.com
Since tumor cells are known to express heat shock proteins (HSPs) as a response to cellular
stress, such as heat, our goal was to determine the expression of HSPs in human …

Heat stress induced cell death mechanisms in hepatocytes and hepatocellular carcinoma: in vitro and in vivo study

SM Thompson, MR Callstrom… - Lasers in surgery …, 2014 - Wiley Online Library
ABSTRACT Background and Objective The aims of the present study were to investigate the
thermal‐dose dependent effect of heat stress on hepatocyte and HCC cell death …

[HTML][HTML] Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma

J Jiang, S Chen, K Li, C Zhang, Y Tan… - International Journal …, 2019 - Taylor & Francis
Purpose: Radiofrequency ablation (RFA) is widely accepted as a curative treatment for small
hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can lead to rapid local …

Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo

G Schueller, J Kettenbach… - International …, 2004 - spandidos-publications.com
Heat shock proteins (HSPs) are known to be of crucial importance in host-tumor interactions.
The goal of this study was to determine whether there was an increase in HSP expression in …

Overexpression of heat shock protein 70 and spontaneous cancer cell apoptosis in hepatocellular carcinoma

Y Yin, Q Qin, W Zhang, J Zhao, C Zhang… - Zhonghua gan Zang …, 2001 - europepmc.org
Objective To evaluate the expression of heat shock protein 70 (HSP70) and its relation to
spontaneous cancer cell apoptosis in hepatocellular carcinoma (HCC). Methods A series of …

Heat-shock pre-treatment reduces liver injury and aids liver recovery after partial hepatectomy in mice

Y Oka, Y Akagi, T Kinugasa, N Ishibashi… - Anticancer …, 2013 - ar.iiarjournals.org
Background: Heat-shock proteins (HSPs) are members of a chaperone protein family
reported to modify stress responses. The aim of this study was to clarify the hypothesis of …

Inhibition of autophagy enhances heat-induced apoptosis in human non-small cell lung cancer cells through ER stress pathways

WY Xie, XD Zhou, J Yang, LX Chen, DH Ran - Archives of biochemistry …, 2016 - Elsevier
The occurrence and mechanisms of autophagy induced by heat stress are not well known in
lung cancer cells. Here, we have demonstrated that heat stress induces autophagy in A549 …