Systematic review of extracellular vesicle‐based treatments for lung injury: are EVs a potential therapy for COVID‐19?

K Khalaj, RL Figueira, L Antounians… - Journal of …, 2020 - Wiley Online Library
Severe COVID‐19 infection results in bilateral interstitial pneumonia, often leading to acute
respiratory distress syndrome (ARDS) and pulmonary fibrosis in survivors. Most patients with …

[HTML][HTML] Can stem cells beat COVID-19: advancing stem cells and extracellular vesicles toward mainstream medicine for lung injuries associated with SARS-CoV-2 …

W Chrzanowski, SY Kim, L McClements - Frontiers in Bioengineering …, 2020 - frontiersin.org
A number of medicines are currently under investigation for the treatment of COVID-19
disease including anti-viral, anti-malarial and anti-inflammatory agents. While these …

[HTML][HTML] Extracellular vesicle-based therapy for COVID-19: promises, challenges and future prospects

V Karn, S Ahmed, LW Tsai, R Dubey, S Ojha, HN Singh… - Biomedicines, 2021 - mdpi.com
The COVID-19 pandemic has become a serious concern and has negatively impacted
public health and the economy. It primarily targets the lungs, causing acute respiratory …

[HTML][HTML] Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage

N Pillalamarri, G Ren, L Khan, A Ullah, S Jonnakuti… - Translational …, 2021 - Elsevier
Extracellular vesicles (EVs) have emerged as potential mediators of intercellular
communication. EVs are nano-sized, lipid membrane–bound vesicles that contains …

[HTML][HTML] Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients

S Al-Khawaga, EM Abdelalim - Stem cell research & therapy, 2020 - Springer
The COVID-19 pandemic has negatively impacted the global public health and the
international economy; therefore, there is an urgent need for an effective therapy to treat …

Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome

A Abraham, A Krasnodembskaya - Stem Cells Translational …, 2020 - academic.oup.com
Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute
inflammatory lung condition which currently has no specific treatments targeting its …

COVID-19 and extracellular vesicles: an intriguing interplay

G Pocsfalvi, R Mammadova… - Kidney and Blood …, 2020 - karger.com
Background: The outbreak of severe acute respiratory syndrome β-coronavirus 2 (SARS-
CoV-2) has the potential to become a long-lasting global health crisis. The number of people …

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges …

S Moradinasab, A Pourbagheri-Sigaroodi… - International …, 2021 - Elsevier
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan city, Hubei province,
China. Rapidly escalated into a worldwide pandemic, it has caused an unprecedented and …

Hypothesis for the management and treatment of the COVID-19-induced acute respiratory distress syndrome and lung injury using mesenchymal stem cell-derived …

M Taghavi-Farahabadi, M Mahmoudi, S Soudi… - Medical hypotheses, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the
coronaviridae that causes respiratory disorders. After infection, large amounts of …

[HTML][HTML] Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective

A Gupta, S Kashte, M Gupta, HC Rodriguez… - Human cell, 2020 - Springer
Acute respiratory distress syndrome (ARDS) is the main cause for the COVID-19 infection-
related morbidity and mortality. Recent clinical evidences suggest increased level of …