Human uterine NK cells have a similar repertoire of killer inhibitory and activatory receptors to those found in blood, as demonstrated by RT-PCR and sequencing
SE Hiby, A King, AM Sharkey, YW Loke - Molecular immunology, 1997 - Elsevier
The expression of natural killer (NK) cell receptors specific for HLA class I molecules has
been studied in CD56bright, CD3− NK cells isolated from the pregnant uterine mucosa, the …
been studied in CD56bright, CD3− NK cells isolated from the pregnant uterine mucosa, the …
The effect of pregnancy on the uterine NK cell KIR repertoire
The major leukocyte population in the decidua during the first trimester of pregnancy
consists of NK cells that express receptors capable of recognizing MHC class I molecules …
consists of NK cells that express receptors capable of recognizing MHC class I molecules …
Expression of killer cell inhibitory receptors on human uterine natural killer cells
S Verma, A King, YW Loke - European journal of immunology, 1997 - Wiley Online Library
The establishment of the human placenta in early pregnancy is characterized by the
presence of large numbers of natural killer (NK) cells within the maternal decidua in close …
presence of large numbers of natural killer (NK) cells within the maternal decidua in close …
Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age
AM Sharkey, L Gardner, S Hiby, L Farrell… - The Journal of …, 2008 - journals.aai.org
Immunogenetic studies suggest that interactions between maternal killer Ig-like receptor
(KIR) expressed by uterine NK (uNK) cells, and fetal HLA-C molecules on trophoblast …
(KIR) expressed by uterine NK (uNK) cells, and fetal HLA-C molecules on trophoblast …
Natural killer cell-mediated recognition of human trophoblast
Large numbers of natural killer cells are present within the maternal decidua close to the
extravillous trophoblast cells. Most of these natural killer cells express high levels of …
extravillous trophoblast cells. Most of these natural killer cells express high levels of …
Role of a KIR/HLA-C allorecognition system in pregnancy
M Varla-Leftherioti - Journal of reproductive immunology, 2004 - Elsevier
Decidual natural killer (NK) cells are thought to play a significant role in the allorecognition
mechanisms during pregnancy. Through their activating and inhibitory receptors they may …
mechanisms during pregnancy. Through their activating and inhibitory receptors they may …
Maternal KIR and fetal HLA-C: a fine balance
ABSTRACT NK cell effector function is regulated by a range of activating and inhibitory
receptors, and many of their known ligands are MHC class I molecules. Human NK …
receptors, and many of their known ligands are MHC class I molecules. Human NK …
Human uterine lymphocytes
A King, T Burrows, S Verma, S Hiby… - Human reproduction …, 1998 - academic.oup.com
During the luteal phase and the early months of pregnancy, there is a dense mucosal
infiltration of CD56+ natural killer (NK) cells. These uterine NK cells have a phenotype …
infiltration of CD56+ natural killer (NK) cells. These uterine NK cells have a phenotype …
p49, A putative HLA-G1-specific inhibitory NK receptor belonging to the Immunoglobulin Superfamily
NK cells display several killer inhibitory receptors (KIRs) specific for different alleles of major
histocompatibility complex (MHC) class I molecules. A family of KIRs are represented by …
histocompatibility complex (MHC) class I molecules. A family of KIRs are represented by …
NK receptor interactions with MHC class I molecules in pregnancy
J Trowsdale, A Moffett - Seminars in immunology, 2008 - Elsevier
Both HLA class I molecules and their receptors on Natural Killer cells, the KIR molecules,
are highly polymorphic. It is generally believed that this variation is driven in response to the …
are highly polymorphic. It is generally believed that this variation is driven in response to the …