Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances

Y Ren, J Whittard, A Higuera-Matas… - Journal of …, 2009 - Soc Neuroscience
There remains debate regarding the impact of cannabis on neuropsychiatric disorders.
Here, we examined the effects of cannabidiol (CBD), a nonpsychoactive constituent of …

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

AJ Kesner, DM Lovinger - Journal of neurochemistry, 2021 - Wiley Online Library
Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus

MÁ Luján, A Castro-Zavala, L Alegre-Zurano… - …, 2018 - Elsevier
Cannabinoid derivatives have shown promising results for treating neuropsychiatric
disorders, including drug addiction. Recent studies on the therapeutic effects of Cannabidiol …

A model of Δ9-tetrahydrocannabinol self-administration and reinstatement that alters synaptic plasticity in nucleus accumbens

S Spencer, D Neuhofer, VC Chioma, C Garcia-Keller… - Biological …, 2018 - Elsevier
Background Cannabis is the most widely used illicit drug, but knowledge of the neurological
consequences of cannabis use is deficient. Two primary components of cannabis are Δ 9 …

Cannabidiol and substance use disorder: Dream or reality

S Karimi-Haghighi, Y Razavi, D Iezzi, AF Scheyer… - …, 2022 - Elsevier
Background Cannabidiol (CBD) is one of the major constituents of Cannabis sativa L. that
lacks psychotomimetic and rewarding properties and inhibits the rewarding and reinforcing …

A brain on cannabinoids: the role of dopamine release in reward seeking

EB Oleson, JF Cheer - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Increases in mesolimbic dopamine transmission are observed when animals are treated
with all known drugs of abuse, including cannabis, and to conditioned stimuli predicting their …

Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: a review of possible mechanisms

C Calpe-López, MP García-Pardo, MA Aguilar - Molecules, 2019 - mdpi.com
Currently, there are no approved pharmacotherapies for addiction to cocaine and other
psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a …

Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats

TG Freels, LN Baxter-Potter, JM Lugo… - Journal of …, 2020 - Soc Neuroscience
Recent trends in cannabis legalization have increased the necessity to better understand
the effects of cannabis use. Animal models involving traditional cannabinoid self …

Brain imaging studies on the cognitive, pharmacological and neurobiological effects of cannabis in humans: evidence from studies of adult users

A Weinstein, A Livny, A Weizman - Current pharmaceutical …, 2016 - ingentaconnect.com
Cannabis is the most widely used illicit drug worldwide. Regular cannabis use has been
associated with a range of acute and chronic mental health problems, such as anxiety …

Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT1A and TRPV1 receptor mechanisms

E Galaj, GH Bi, HJ Yang, ZX Xi - Neuropharmacology, 2020 - Elsevier
Cocaine abuse continues to be a serious health problem worldwide. Despite intense
research there is currently no FDA-approved medication to treat cocaine use disorder. The …