IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …

Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …

Interleukin (IL)-6 cDNA was originally cloned as a terminal B cell differentiation factor into
antibody-producing plasma cells. This revealed that it is a multifunctional cytokine that acts …

Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …

Immune cells secrete small protein molecules that aim for cell–cell communications. These
small molecules are called cytokines. Targeting cancer cells with administration of bispecific …

The IL-1 family comprises two anti-inflammatory cytokines (IL-37, IL-38), two receptor
antagonists (IL-1ra, IL-36ra), and seven ligand agonists (IL-1α, IL-1β, IL-33, IL-36α, IL-36β …

Abstract Interleukin-6 (IL-6) is a cytokine with redundant and pleiotropic activities, and its
synthesis is tightly regulated by transcriptional and posttranscriptional mechanisms. When …

Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …

Sepsis and septic shock are a major cause of morbidity and mortality in patients admitted to
the intensive care unit. Since the introduction of antibiotic therapy, the mortality associated …

IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …