The degeneration of forebrain dopamine systems in Parkinson's disease has been an
effective target for pharmaceutical research over the past four decades. However, although …

Advances in understanding the molecular mechanisms of cell death and the pathogenesis
of sporadic and familial Parkinson's disease are creating new opportunities for the …

Parkinson's disease is a neurodegenerative process characterized by numerous motor and
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …

Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra.
Similar to other major neurodegenerative disorders, there are no disease-modifying …

Parkinson's disease: a model dilemma | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Parkinson's disease is a debilitating, age-associated movement disorder. A central aspect of
the pathophysiology of Parkinson's disease is the progressive demise of midbrain dopamine …

Several factors are known to be capable of inducing relatively selective dopaminergic cell
death in the substantia nigra and inducing the clinical features that characterize Parkinson's …

Parkinson's disease was first described in 1817 by James Parkinson. It is one of the most
common neurodegenerative disorders, affecting the nigrostriatal pathways involved in the …

Abstract FOR SEVERAL DECADES, the clinical study of Parkinson's disease has driven an
increasingly sophisticated understanding of the dopaminergic system and its complex role in …

Parkinson disease (PD) is a relatively common disorder of the nervous system that afflicts
patients later in life with tremor, slowness of movement, gait instability, and rigidity …