The genetics of Crohn's disease and ulcerative colitis – status quo and beyond

D Ellinghaus, J Bethune, BS Petersen… - Scandinavian journal of …, 2015 - Taylor & Francis
The two major subtypes of inflammatory bowel disease (IBD), ulcerative colitis (UC, MIM#
191390) and Crohn's disease (CD, MIM# 266600), are chronic relapsing-remitting …

New IBD genetics: common pathways with other diseases

CW Lees, JC Barrett, M Parkes, J Satsangi - Gut, 2011 - gut.bmj.com
Complex disease genetics has been revolutionised in recent years by the advent of genome-
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's …

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

K Wang, R Baldassano, H Zhang, HQ Qu… - Human molecular …, 2010 - academic.oup.com
Inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis (UC), and
type 1 diabetes (T1D) are autoimmune diseases that may share common susceptibility …

[HTML][HTML] The history of genetics in inflammatory bowel disease

WE Ek, M D'Amato, J Halfvarson - Annals of gastroenterology …, 2014 - ncbi.nlm.nih.gov
The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially
demonstrated by epidemiological data, including differences in prevalence among different …

Recent insights into the genetics of inflammatory bowel disease

JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …

The genetic background of inflammatory bowel disease: from correlation to causality

WTC Uniken Venema, MD Voskuil… - The Journal of …, 2017 - Wiley Online Library
Recent studies have greatly improved our insight into the genetic background of
inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale …

Impact of genes and the environment on the pathogenesis and disease course of inflammatory bowel disease

M Zhao, J Burisch - Digestive diseases and sciences, 2019 - Springer
Crohn's disease and ulcerative colitis constitute two major subgroups of inflammatory bowel
diseases (IBD), a group of complex polygenic diseases characterized by chronic and …

Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

The epidemiology of inflammatory bowel disease: East meets west

WY Mak, M Zhao, SC Ng… - Journal of gastroenterology …, 2020 - Wiley Online Library
The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade
to become a global disease. The increasing number of studies on the incidence and course …

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

Y Luo, KM De Lange, L Jostins, L Moutsianas… - Nature …, 2017 - nature.com
To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …