We present a novel single-molecule method for rapidly evaluating small-molecule binding to
individual DNA molecules using nanopores fabricated in ultrathin silicon membranes. A …

Nanometer-sized pores can be used to detect and characterize biopolymers, such as DNA,
RNA, and polypeptides, with single-molecule resolution. Experiments performed with the 1.5 …

Nanopore-based DNA analysis is a new single-molecule technique that involves monitoring
the flow of ions through a narrow pore, and detecting changes in this flow as DNA molecules …

Nanopores have emerged as a prominent single‐molecule analytic tool with particular
promise for genomic applications. In this review, we discuss two potential applications of the …

The challenge when employing solid-state nanopores as single-molecule sensors in a given
assay is the specificity of the ionic current signal during the translocation of target molecules …

Understanding the biophysics governing single-molecule transport through solid-state
nanopores is of fundamental importance in working toward the goal of DNA detection and …

Engineered Nanopores for Bioanalytical Applications is the first book to focus primarily on
practical analytical applications of nanopore development. These nanoscale analytical …

Recent developments in nanopore devices are re-examined from the perspective of their
selectivity for detecting single or multiple analytes. Although nanopore devices have been …

Nanopore technology is a promising label-free detection method. However, challenges exist
for its further application in sequencing, clinical diagnostics and ultra-sensitive single …

While conventional solid-state nanopore measurements utilize ionic current, there is a
growing interest in alternative sensing paradigms, including optical detection. However, a …