Purpose. Diabetes mellitus (DM) is a risk factor for open-angle glaucoma, although the
mechanistic interrelationship of the two is debatable. The purpose of this study is to test …

We developed and characterized a mouse model of elevated intraocular pressure (IOP) to
investigate the underlying cellular and genetic mechanisms of retinal ganglion cell (RGC) …

purpose. To investigate the effect of IOP on retinal ganglion cell (RGC) apoptosis and
correlate the effects with IOP-induced changes in extracellular matrix (ECM) in the retina and …

Purpose: Glaucoma is a multifactorial disease, causing retinal ganglion cells (RGCs) and
optic nerve degeneration. The role of diabetes as a risk factor for glaucoma has been …

The purpose of this study was to design an animal model mimicking glaucoma with
hemodynamic instability and to identify involvement of angiotensin II (AngII) and associated …

Purpose To investigate age-associated changes in retinal ganglion cell (RGC) response to
elevated intraocular pressure (IOP), and to explore the mechanism underlying these …

Open-angle glaucoma (OAG) is an optic neuropathy characterized by progressive retinal
ganglion cell (RGC) death and optic disk excavation. Evidence is accumulating that RGC …

The Akt serine/threonine kinase mediates pro-survival signalings in retina and was reported
to be activated in a response to some retinal and optic nerve injuries. Human and …

Purpose To study alterations in different retinal cell types associated with retinal ganglion
cell (RGC) death after elevation of intraocular pressure (IOP) in rats. Methods IOP was …

Purpose: Retinal ganglion cell death occurs during the glaucoma pathological process, and
it is significant because of the poor regeneration capacity of retinal ganglion cells. With a …